Methylphenidate and Paranoia - a phase IV clinical study of FDA data

Summary:

Paranoia is reported as a side effect among people who take Methylphenidate (methylphenidate), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Naloxone, and have Psychotic disorder.

The phase IV clinical study analyzes which people have Paranoia when taking Methylphenidate. It is created by eHealthMe based on reports of 8,120 people who have side effects when taking Methylphenidate from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,217 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Paranoia?

Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur) is found to be associated with 1,040 drugs and 1,276 conditions by eHealthMe. Check the latest studies of Paranoia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

8,120 people reported to have side effects when taking Methylphenidate.
Among them, 55 people (0.68%) have Paranoia.

Among these 55 people:

How long have people been on Methylphenidate when they have Paranoia? *

What is the gender of people who have Paranoia when taking Methylphenidate? *

female: 19.61 %
male: 80.39 %

What is the age of people who have Paranoia when taking Methylphenidate? *

What are other drugs people take besides Methylphenidate? *

What are other side effects people have besides Paranoia? *

Aggression: 38 people, 69.09%
Drug Ineffective: 38 people, 69.09%
Hallucinations (sensations that appear real but are created by your mind): 35 people, 63.64%
Delusion (a false belief or opinion): 33 people, 60.00%
Hallucination, Visual (seeing things that aren't there): 32 people, 58.18%
Drug Dependence: 31 people, 56.36%
Mood Swings (an extreme or rapid change in mood): 11 people, 20.00%
Feeling Abnormal: 10 people, 18.18%
Pain: 9 people, 16.36%
Feeling Hot: 8 people, 14.55%

What are the existing conditions these people have? *

Depression: 32 people, 58.18%
Psychotic Disorder: 32 people, 58.18%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 16 people, 29.09%
Oral Herpes (viral infection of mouth): 5 people, 9.09%
High Blood Pressure: 5 people, 9.09%
Stress And Anxiety: 4 people, 7.27%
Growth Hormone Deficiency: 4 people, 7.27%
Immunodeficiency Common Variable: 2 people, 3.64%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 3.64%
Movement - Uncontrolled Or Slow: 2 people, 3.64%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate and have Paranoia?

- Check whether Paranoia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylphenidate:

Methylphenidate (8,217 reports)

Paranoia treatments and more:

Paranoia (23,921 reports)

Browse all side effects of Methylphenidate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Paranoia:

Paranoia (1,040 drugs)

Browse all the conditions that are associated with Paranoia:

Paranoia (1,276 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate (the active ingredients of Methylphenidate) and Methylphenidate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.