Methylphenidate and Precocious puberty - a phase IV clinical study of FDA data

Summary:

Precocious puberty is reported as a side effect among people who take Methylphenidate (methylphenidate), especially for people who are female, 2-9 old, also take Ketoconazole, and have Attention deficit hyperactivity disorder.

The phase IV clinical study analyzes which people have Precocious puberty when taking Methylphenidate. It is created by eHealthMe based on reports of 8,120 people who have side effects when taking Methylphenidate from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,217 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Precocious puberty?

Precocious puberty is found to be associated with 40 drugs and 172 conditions by eHealthMe. Check the latest studies of Precocious puberty.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

8,120 people reported to have side effects when taking Methylphenidate.
Among them, 33 people (0.41%) have Precocious puberty.

Could Methylphenidate cause Precocious puberty?

Among these 33 people:

What is the gender of people who have Precocious puberty when taking Methylphenidate? *

female: 53.85 %
male: 46.15 %

What is the age of people who have Precocious puberty when taking Methylphenidate? *

What are other drugs people take besides Methylphenidate? *

Fluoxetine: 5 people, 15.15%
Xyrem: 5 people, 15.15%
Tretinoin: 5 people, 15.15%
Doxycycline: 5 people, 15.15%
Epinephrine: 5 people, 15.15%
Ketoconazole: 5 people, 15.15%
Zyrtec: 4 people, 12.12%
Vitamins: 4 people, 12.12%
Atomoxetine Hydrochloride: 4 people, 12.12%
Auvi-Q: 4 people, 12.12%

What are other side effects people have besides Precocious puberty? *

Skin Papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections): 5 people, 15.15%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 5 people, 15.15%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 5 people, 15.15%
Stress And Anxiety: 3 people, 9.09%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 2 people, 6.06%
Menstrual Disorder (disease of menstrual cycle): 2 people, 6.06%
Hyperhidrosis (abnormally increased sweating): 2 people, 6.06%
Gynecomastia (enlargement of the gland tissue of the male breast): 2 people, 6.06%
Dyskinesia (abnormality or impairment of voluntary movement): 2 people, 6.06%
Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 1 person, 3.03%

What are the existing conditions these people have? *

Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 26 people, 78.79%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 15.15%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 15.15%
Drowsiness: 3 people, 9.09%
Stress And Anxiety: 2 people, 6.06%
Sleep Disorder: 2 people, 6.06%
Autism Spectrum Disorder (developmental disabilities that can cause significant social, communication and behavioural challenges): 2 people, 6.06%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 1 person, 3.03%
Growth Hormone Deficiency: 1 person, 3.03%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate and have Precocious puberty?

- Check whether Precocious puberty is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylphenidate:

Methylphenidate (8,217 reports)

Browse all side effects of Methylphenidate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Precocious puberty:

Precocious puberty (40 drugs)

Browse all the conditions that are associated with Precocious puberty:

Precocious puberty (172 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate (the active ingredients of Methylphenidate) and Methylphenidate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.