Metrogel and Restless leg syndrome - a phase IV clinical study of FDA data

Summary:

Restless leg syndrome is reported as a side effect among people who take Metrogel (metronidazole), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Vitamin B12, and have Dry mouth.

The phase IV clinical study analyzes which people have Restless leg syndrome when taking Metrogel. It is created by eHealthMe based on reports of 2,715 people who have side effects when taking Metrogel from the FDA, and is updated regularly.

What is Metrogel?

Metrogel has active ingredients of metronidazole. It is often used in rosacea. eHealthMe is studying from 2,819 Metrogel users. Check the latest studies of Metrogel.

What is Restless leg syndrome?

Restless leg syndrome (a powerful urge to move your legs) is found to be associated with 1,245 drugs and 1,934 conditions by eHealthMe. Check the latest studies of Restless leg syndrome.

On Jul, 16, 2026

2,715 people reported to have side effects when taking Metrogel.
Among them, 12 people (0.44%) have Restless leg syndrome.

Could Metrogel cause Restless leg syndrome?

Among these 12 people:

How long have people been on Metrogel when they have Restless leg syndrome? *

What is the gender of people who have Restless leg syndrome when taking Metrogel? *

female: 58.33 %
male: 41.67 %

What is the age of people who have Restless leg syndrome when taking Metrogel? *

What are other drugs people take besides Metrogel? *

What are other side effects people have besides Restless leg syndrome? *

Neuropathy Peripheral (surface nerve damage): 6 people, 50.00%
Pain In Extremity: 4 people, 33.33%
Hypoaesthesia (reduced sense of touch or sensation): 3 people, 25.00%
Erection Problems: 3 people, 25.00%
Arrhythmias (irregular heartbeat): 3 people, 25.00%
Iron Deficiency Anaemia: 2 people, 16.67%
Muscle Spasms (muscle contraction): 2 people, 16.67%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 16.67%
Connective Tissue Disorder (any disease that has the connective tissues of the body): 2 people, 16.67%
Pain: 2 people, 16.67%

What are the existing conditions these people have? *

Pain: 2 people, 16.67%
Nasopharyngitis (inflammation of the nasopharynx): 2 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 16.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 16.67%
Dry Mouth: 2 people, 16.67%
Impaired Gastric Emptying: 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%
Drowsiness: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Metrogel and have Restless leg syndrome?

- Check whether Restless leg syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metrogel:

Metrogel (2,819 reports)

Browse all side effects of Metrogel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Restless leg syndrome:

Restless leg syndrome (1,245 drugs)

Browse all the conditions that are associated with Restless leg syndrome:

Restless leg syndrome (1,934 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metronidazole (the active ingredients of Metrogel) and Metrogel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.