Midodrine hydrochloride and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is reported as a side effect among people who take Midodrine hydrochloride (midodrine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Lyrica, and have Muscle spasms.

The phase IV clinical study analyzes which people have Constipation when taking Midodrine hydrochloride. It is created by eHealthMe based on reports of 3,007 people who have side effects when taking Midodrine hydrochloride from the FDA, and is updated regularly.

What is Midodrine hydrochloride?

Midodrine hydrochloride has active ingredients of midodrine hydrochloride. It is often used in hypotension. eHealthMe is studying from 3,275 Midodrine hydrochloride users. Check the latest studies of Midodrine hydrochloride.

What is Constipation?

Constipation is found to be associated with 3,004 drugs and 4,619 conditions by eHealthMe. Check the latest studies of Constipation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

3,007 people reported to have side effects when taking Midodrine hydrochloride.
Among them, 60 people (2.0%) have Constipation.

Could Midodrine hydrochloride cause Constipation?

Among these 60 people:

How long have people been on Midodrine hydrochloride when they have Constipation? *

What is the gender of people who have Constipation when taking Midodrine hydrochloride? *

female: 37.25 %
male: 62.75 %

What is the age of people who have Constipation when taking Midodrine hydrochloride? *

What are other drugs people take besides Midodrine hydrochloride? *

Lyrica: 12 people, 20.00%
Vitamins: 11 people, 18.33%
Aspirin: 11 people, 18.33%
Spironolactone: 11 people, 18.33%
Famotidine: 10 people, 16.67%
Nuplazid: 10 people, 16.67%
Onpattro: 9 people, 15.00%
Polaramine: 9 people, 15.00%
Xylocaine: 9 people, 15.00%
Fexofenadine Hydrochloride: 8 people, 13.33%

What are other side effects people have besides Constipation? *

Weakness: 21 people, 35.00%
Fall: 21 people, 35.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 26.67%
Balance Disorder: 12 people, 20.00%
Fatigue (feeling of tiredness): 12 people, 20.00%
Oedema Peripheral (superficial swelling): 11 people, 18.33%
Dizziness: 11 people, 18.33%
Weight Decreased: 11 people, 18.33%
Drowsiness: 11 people, 18.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 16.67%

What are the existing conditions these people have? *

Muscle Spasms (muscle contraction): 14 people, 23.33%
Parkinson's Disease: 13 people, 21.67%
Vitamin B1 Deficiency: 9 people, 15.00%
Allergic Rhinitis: 9 people, 15.00%
Cardiac Failure: 9 people, 15.00%
Diarrhea: 9 people, 15.00%
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon): 9 people, 15.00%
Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 9 people, 15.00%
Neuropathy Peripheral (surface nerve damage): 9 people, 15.00%
Hypokalemia (low potassium): 9 people, 15.00%

* Approximation only. Some reports may have incomplete information.

Do you take Midodrine hydrochloride and have Constipation?

- Check whether Constipation is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Midodrine hydrochloride:

Midodrine hydrochloride (3,275 reports)

Constipation treatments and more:

Constipation (337,881 reports)

Browse all side effects of Midodrine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation:

Constipation (3,004 drugs)

Browse all the conditions that are associated with Constipation:

Constipation (4,619 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on midodrine hydrochloride (the active ingredients of Midodrine hydrochloride) and Midodrine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.