Mirena and Bone pain aggravated - a phase IV clinical study of FDA data

Summary:

Bone pain aggravated is reported as a side effect among people who take Mirena (levonorgestrel), especially for people who are female, 20-29 old, have been taking the drug for 2 - 5 years also take Nexium, and have Depression.

The phase IV clinical study analyzes which people have Bone pain aggravated when taking Mirena. It is created by eHealthMe based on reports of 143,466 people who have side effects when taking Mirena from the FDA, and is updated regularly.

What is Mirena?

Mirena has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 145,266 Mirena users. Check the latest studies of Mirena.

What is Bone pain aggravated?

Bone pain aggravated is found to be associated with 1,421 drugs and 425 conditions by eHealthMe. Check the latest studies of Bone pain aggravated.

On Jul, 14, 2026

143,466 people reported to have side effects when taking Mirena.
Among them, 88 people (0.06%) have Bone pain aggravated.

Could Mirena cause Bone pain aggravated?

Among these 88 people:

How long have people been on Mirena when they have Bone pain aggravated? *

What is the gender of people who have Bone pain aggravated when taking Mirena? *

female: 98.81 %
male: 1.19 %

What is the age of people who have Bone pain aggravated when taking Mirena? *

What are other drugs people take besides Mirena? *

What are other side effects people have besides Bone pain aggravated? *

Fatigue (feeling of tiredness): 29 people, 32.95%
Depression: 28 people, 31.82%
Back Pain: 25 people, 28.41%
Joint Pain: 23 people, 26.14%
Weight Increased: 23 people, 26.14%
Headache (pain in head): 21 people, 23.86%
Stress And Anxiety: 18 people, 20.45%
Nausea (feeling of having an urge to vomit): 17 people, 19.32%
Muscle Aches (muscle pain): 17 people, 19.32%
Acne (skin problems that cause pimples): 16 people, 18.18%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 9.09%
Depression: 8 people, 9.09%
Pain: 4 people, 4.55%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 4.55%
Metastases To Bone (cancer spreads to bone): 4 people, 4.55%
High Blood Pressure: 3 people, 3.41%
Stress And Anxiety: 3 people, 3.41%
Multiple Myeloma (cancer of the plasma cells): 3 people, 3.41%
Osteoporosis (bones weak and more likely to break): 2 people, 2.27%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 2.27%

* Approximation only. Some reports may have incomplete information.

Do you take Mirena and have Bone pain aggravated?

- Check whether Bone pain aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Mirena:

Mirena (145,266 reports)

Browse all side effects of Mirena:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone pain aggravated:

Bone pain aggravated (1,421 drugs)

Browse all the conditions that are associated with Bone pain aggravated:

Bone pain aggravated (425 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levonorgestrel (the active ingredients of Mirena) and Mirena (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.