Mirena and Retching - a phase IV clinical study of FDA data

Summary:

Retching is reported as a side effect among people who take Mirena (levonorgestrel), especially for people who are female, 20-29 old, have been taking the drug for 2 - 5 years also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Retching when taking Mirena. It is created by eHealthMe based on reports of 143,466 people who have side effects when taking Mirena from the FDA, and is updated regularly.

What is Mirena?

Mirena has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 145,266 Mirena users. Check the latest studies of Mirena.

What is Retching?

Retching (strong involuntary effort to vomit) is found to be associated with 1,234 drugs and 1,248 conditions by eHealthMe. Check the latest studies of Retching.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

143,466 people reported to have side effects when taking Mirena.
Among them, 39 people (0.03%) have Retching.

Among these 39 people:

How long have people been on Mirena when they have Retching? *

What is the gender of people who have Retching when taking Mirena? *

female: 100 %
male: 0.0 %

What is the age of people who have Retching when taking Mirena? *

What are other drugs people take besides Mirena? *

What are other side effects people have besides Retching? *

Nausea And Vomiting: 20 people, 51.28%
Nausea (feeling of having an urge to vomit): 18 people, 46.15%
Feeling Abnormal: 15 people, 38.46%
Crying: 10 people, 25.64%
Cough: 9 people, 23.08%
The Flu (the flu is caused by an influenza virus): 8 people, 20.51%
Depressed Level Of Consciousness: 8 people, 20.51%
Depression: 7 people, 17.95%
Kidney Stones: 7 people, 17.95%
Bronchitis Chronic (inflammation of the mucous membrane in the bronchial tubes- chronic): 7 people, 17.95%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 48.72%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 16 people, 41.03%
Depression: 9 people, 23.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 23.08%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 8 people, 20.51%
Intracranial Pressure Increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid): 8 people, 20.51%
Asthma: 8 people, 20.51%
Blood Potassium Decreased: 8 people, 20.51%
Cluster Headache (one-sided head pain with tearing): 8 people, 20.51%
Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 20.51%

* Approximation only. Some reports may have incomplete information.

Do you take Mirena and have Retching?

- Check whether Retching is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Mirena:

Mirena (145,266 reports)

Retching treatments and more:

Retching (23,331 reports)

Browse all side effects of Mirena:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Retching:

Retching (1,234 drugs)

Browse all the conditions that are associated with Retching:

Retching (1,248 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levonorgestrel (the active ingredients of Mirena) and Mirena (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.