Tavneos and Cholestasis - a phase IV clinical study of FDA data

Summary:

Cholestasis is reported as a side effect among people who take Tavneos (avacopan), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Prednisolone, and have Microscopic polyangiitis.

The phase IV clinical study analyzes which people have Cholestasis when taking Tavneos. It is created by eHealthMe based on reports of 2,521 people who have side effects when taking Tavneos from the FDA, and is updated regularly.

What is Tavneos?

Tavneos has active ingredients of avacopan. eHealthMe is studying from 2,522 Tavneos users. Check the latest studies of Tavneos.

What is Cholestasis?

Cholestasis (a condition where bile cannot flow from the liver to the duodenum) is found to be associated with 1,032 drugs and 1,814 conditions by eHealthMe. Check the latest studies of Cholestasis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

2,521 people reported to have side effects when taking Tavneos.
Among them, 16 people (0.63%) have Cholestasis.

Among these 16 people:

How long have people been on Tavneos when they have Cholestasis? *

What is the gender of people who have Cholestasis when taking Tavneos? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Cholestasis when taking Tavneos? *

What are other drugs people take besides Tavneos? *

What are other side effects people have besides Cholestasis? *

Drug-Induced Liver Injury (diseases of the liver that are caused by physician-prescribed medications): 5 people, 31.25%
Vanishing Bile Duct Syndrome (loose collection of diseases which leads to the injury to hepatic bile ducts and eventual ductopenia): 5 people, 31.25%
Yellow Skin: 4 people, 25.00%
Hepatic Function Abnormal: 4 people, 25.00%
Blood Bilirubin Increased: 4 people, 25.00%
Cholangitis (infection of the bile duct): 4 people, 25.00%
Gallbladder Enlargement: 4 people, 25.00%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 25.00%
Hepatic Enzyme Increased: 4 people, 25.00%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 25.00%

What are the existing conditions these people have? *

Microscopic Polyangiitis (inflammation involving multiple blood or lymph small-vessel): 13 people, 81.25%
Insomnia (sleeplessness): 5 people, 31.25%
High Blood Pressure: 5 people, 31.25%
Depression: 4 people, 25.00%
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 4 people, 25.00%
Abdominal Discomfort: 4 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 18.75%
Vanishing Bile Duct Syndrome (loose collection of diseases which leads to the injury to hepatic bile ducts and eventual ductopenia): 2 people, 12.50%
Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 6.25%
Stress And Anxiety: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Tavneos and have Cholestasis?

- Check whether Cholestasis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tavneos:

Tavneos (2,522 reports)

Cholestasis treatments and more:

Cholestasis (23,731 reports)

Browse all side effects of Tavneos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cholestasis:

Cholestasis (1,032 drugs)

Browse all the conditions that are associated with Cholestasis:

Cholestasis (1,814 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on avacopan (the active ingredients of Tavneos) and Tavneos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.