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Modafinil and Hearing loss - a phase IV clinical study of FDA data

Summary:

Hearing loss is reported as a side effect among people who take Modafinil (modafinil), especially for people who are female, 30-39 old, have been taking the drug for 2 - 5 years also take Xyrem, and have Cataplexy.

The phase IV clinical study analyzes which people have Hearing loss when taking Modafinil. It is created by eHealthMe based on reports of 19,891 people who have side effects when taking Modafinil from the FDA, and is updated regularly.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

What is Hearing loss?

Hearing loss is found to be associated with 1,357 drugs and 2,388 conditions by eHealthMe. Check the latest studies of Hearing loss.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

19,891 people reported to have side effects when taking Modafinil.
Among them, 27 people (0.14%) have Hearing loss.

Could Modafinil cause Hearing loss?

Among these 27 people:

How long have people been on Modafinil when they have Hearing loss? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hearing loss when taking Modafinil? *

  • female: 88.46 %
  • male: 11.54 %

What is the age of people who have Hearing loss when taking Modafinil? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 40.0 %
  • 40-49: 6.67 %
  • 50-59: 20.0 %
  • 60+: 33.33 %

What are other drugs people take besides Modafinil? *

  1. Xyrem: 15 people, 55.56%
  2. Synthroid: 7 people, 25.93%
  3. Adderall: 7 people, 25.93%
  4. Vitamin D3: 7 people, 25.93%
  5. Norco: 6 people, 22.22%
  6. Vitamin B12: 6 people, 22.22%
  7. Flonase Allergy Relief: 5 people, 18.52%
  8. Cymbalta: 5 people, 18.52%
  9. Nitrostat: 4 people, 14.81%
  10. Crestor: 4 people, 14.81%

What are other side effects people have besides Hearing loss? *

  1. Tinnitus (a ringing in the ears): 7 people, 25.93%
  2. Nausea (feeling of having an urge to vomit): 5 people, 18.52%
  3. Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 14.81%
  4. Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 14.81%
  5. Gait Disturbance: 4 people, 14.81%
  6. Headache (pain in head): 4 people, 14.81%
  7. Nausea And Vomiting: 4 people, 14.81%
  8. Fatigue (feeling of tiredness): 4 people, 14.81%
  9. Swallowing Difficulty: 4 people, 14.81%
  10. Weight Increased: 3 people, 11.11%

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 33.33%
  2. Fatigue (feeling of tiredness): 3 people, 11.11%
  3. Osteoporosis (bones weak and more likely to break): 3 people, 11.11%
  4. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 11.11%
  5. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 7.41%
  6. Scoliosis (a medical condition in which a person's spine is curved from side to side): 2 people, 7.41%
  7. Dyskinesia (abnormality or impairment of voluntary movement): 2 people, 7.41%
  8. Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 7.41%
  9. Gastritis (inflammation of stomach): 2 people, 7.41%
  10. High Blood Pressure: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Modafinil and have Hearing loss?

- Check whether Hearing loss is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Modafinil:

Hearing loss treatments and more:

How severe was Hearing loss and when was it recovered:

Expand to all the drugs that have ingredients of modafinil:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Modafinil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hearing loss:

Browse all the conditions that are associated with Hearing loss:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on modafinil (the active ingredients of Modafinil) and Modafinil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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