Modafinil and Stroke - a phase IV clinical study of FDA data

Summary:

Stroke is reported as a side effect among people who take Modafinil (modafinil), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Xyrem, and have Cataplexy.

The phase IV clinical study analyzes which people have Stroke when taking Modafinil. It is created by eHealthMe based on reports of 19,891 people who have side effects when taking Modafinil from the FDA, and is updated regularly.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,804 Modafinil users. Check the latest studies of Modafinil.

What is Stroke?

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen) is found to be associated with 2,350 drugs and 3,023 conditions by eHealthMe. Check the latest studies of Stroke.

On Apr, 06, 2026

19,891 people reported to have side effects when taking Modafinil.
Among them, 106 people (0.53%) have Stroke.

Among these 106 people:

* Approximation only. Some reports may have incomplete information.

Do you take Modafinil and have Stroke?

- Check whether Stroke is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Modafinil:

Modafinil (20,804 reports)

Stroke treatments and more:

Stroke (334,634 reports)

How severe was Stroke and when was it recovered:

Stroke in Modafinil

Expand to all the drugs that have ingredients of modafinil:

Stroke and drugs with ingredients of modafinil (309 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Modafinil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Stroke:

Stroke (2,350 drugs)

Browse all the conditions that are associated with Stroke:

Stroke (3,023 conditions)

Related publications that referenced our studies

Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on modafinil (the active ingredients of Modafinil) and Modafinil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.