1. Home
  2. Analysis
  3. Modafinil
  4. Systemic-lupus-erythematosus

Modafinil and Systemic lupus erythematosus - a phase IV clinical study of FDA data

Summary:

Systemic lupus erythematosus is reported as a side effect among people who take Modafinil (modafinil), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Xyrem, and have Cataplexy.

The phase IV clinical study analyzes which people have Systemic lupus erythematosus when taking Modafinil. It is created by eHealthMe based on reports of 19,891 people who have side effects when taking Modafinil from the FDA, and is updated regularly.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

What is Systemic lupus erythematosus?

Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue) is found to be associated with 1,089 drugs and 1,642 conditions by eHealthMe. Check the latest studies of Systemic lupus erythematosus.

On Jul, 18, 2026

19,891 people reported to have side effects when taking Modafinil.
Among them, 49 people (0.25%) have Systemic lupus erythematosus.

Could Modafinil cause Systemic lupus erythematosus?

Among these 49 people:

How long have people been on Modafinil when they have Systemic lupus erythematosus? *

  • < 1 month: 33.33 %
  • 1 - 6 months: 11.11 %
  • 6 - 12 months: 11.11 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 11.11 %
  • 10+ years: 0.0 %

What is the gender of people who have Systemic lupus erythematosus when taking Modafinil? *

  • female: 91.84 %
  • male: 8.16 %

What is the age of people who have Systemic lupus erythematosus when taking Modafinil? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 15.79 %
  • 30-39: 21.05 %
  • 40-49: 31.58 %
  • 50-59: 31.58 %
  • 60+: 0.0 %

What are other drugs people take besides Modafinil? *

  1. Xyrem: 41 people, 83.67%
  2. Vitamin D3: 18 people, 36.73%
  3. Adderall: 14 people, 28.57%
  4. Lyrica: 14 people, 28.57%
  5. Proair Hfa: 11 people, 22.45%
  6. Singulair: 9 people, 18.37%
  7. Xanax: 9 people, 18.37%
  8. Lexapro: 9 people, 18.37%
  9. Ventolin Hfa: 9 people, 18.37%
  10. Zyrtec: 8 people, 16.33%

What are other side effects people have besides Systemic lupus erythematosus? *

  1. Weight Decreased: 6 people, 12.24%
  2. Stress And Anxiety: 6 people, 12.24%
  3. Nausea (feeling of having an urge to vomit): 6 people, 12.24%
  4. Abnormal Dreams: 5 people, 10.20%
  5. Drug Ineffective: 5 people, 10.20%
  6. Depression: 5 people, 10.20%
  7. Suicidal Ideation: 5 people, 10.20%
  8. High Blood Pressure: 4 people, 8.16%
  9. Fever: 4 people, 8.16%
  10. Joint Pain: 4 people, 8.16%

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 40.82%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 4.08%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 4.08%
  4. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 2.04%
  5. Neuropathy Peripheral (surface nerve damage): 1 person, 2.04%
  6. Muscle Spasms (muscle contraction): 1 person, 2.04%
  7. Insomnia (sleeplessness): 1 person, 2.04%
  8. Immunodeficiency Common Variable: 1 person, 2.04%
  9. Hypotension (abnormally low blood pressure): 1 person, 2.04%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 2.04%

* Approximation only. Some reports may have incomplete information.

Do you take Modafinil and have Systemic lupus erythematosus?

- Check whether Systemic lupus erythematosus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Modafinil:

Systemic lupus erythematosus treatments and more:

How severe was Systemic lupus erythematosus and when was it recovered:

Expand to all the drugs that have ingredients of modafinil:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Modafinil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic lupus erythematosus:

Browse all the conditions that are associated with Systemic lupus erythematosus:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on modafinil (the active ingredients of Modafinil) and Modafinil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.