Morphine sulfate and Breakthrough pain - a phase IV clinical study of FDA data

Summary:

Breakthrough pain is reported as a side effect among people who take Morphine sulfate (morphine sulfate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Oxycontin, and have Joint pain.

The phase IV clinical study analyzes which people have Breakthrough pain when taking Morphine sulfate. It is created by eHealthMe based on reports of 86,091 people who have side effects when taking Morphine sulfate from the FDA, and is updated regularly.

What is Morphine sulfate?

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 87,262 Morphine sulfate users. Check the latest studies of Morphine sulfate.

What is Breakthrough pain?

Breakthrough pain is found to be associated with 271 drugs and 417 conditions by eHealthMe. Check the latest studies of Breakthrough pain.

On Aug, 02, 2026

86,091 people reported to have side effects when taking Morphine sulfate.
Among them, 55 people (0.06%) have Breakthrough pain.

Could Morphine sulfate cause Breakthrough pain?

Among these 55 people:

How long have people been on Morphine sulfate when they have Breakthrough pain? *

What is the gender of people who have Breakthrough pain when taking Morphine sulfate? *

female: 49.06 %
male: 50.94 %

What is the age of people who have Breakthrough pain when taking Morphine sulfate? *

What are other drugs people take besides Morphine sulfate? *

What are other side effects people have besides Breakthrough pain? *

Fatigue (feeling of tiredness): 19 people, 34.55%
Fall: 17 people, 30.91%
Stress And Anxiety: 17 people, 30.91%
Joint Pain: 17 people, 30.91%
Malaise (a feeling of general discomfort or uneasiness): 16 people, 29.09%
Depression: 16 people, 29.09%
Nausea (feeling of having an urge to vomit): 16 people, 29.09%
Nausea And Vomiting: 14 people, 25.45%
High Blood Pressure: 14 people, 25.45%
Head Injury: 14 people, 25.45%

What are the existing conditions these people have? *

Joint Pain: 13 people, 23.64%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 10 people, 18.18%
Tooth Fracture: 10 people, 18.18%
Neck Pain: 6 people, 10.91%
Stress And Anxiety: 5 people, 9.09%
Dyspnea (difficult or laboured breathing): 4 people, 7.27%
Alcoholism (problems with alcohol): 4 people, 7.27%
Blood Pressure Abnormal: 3 people, 5.45%
Breast Cancer Metastatic: 3 people, 5.45%
Cancer Pain: 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

Do you take Morphine sulfate and have Breakthrough pain?

- Check whether Breakthrough pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Morphine sulfate:

Morphine sulfate (87,262 reports)

Browse all side effects of Morphine sulfate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Breakthrough pain:

Breakthrough pain (271 drugs)

Browse all the conditions that are associated with Breakthrough pain:

Breakthrough pain (417 conditions)

Related publications that referenced our studies

Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate (the active ingredients of Morphine sulfate) and Morphine sulfate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.