Morphine and Hyperacusis - a phase IV clinical study of FDA data

Summary:

Hyperacusis is reported as a side effect among people who take Morphine (morphine sulfate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Hyperacusis when taking Morphine. It is created by eHealthMe based on reports of 180,723 people who have side effects when taking Morphine from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,913 Morphine users. Check the latest studies of Morphine.

What is Hyperacusis?

Hyperacusis (disorder in loudness perception) is found to be associated with 429 drugs and 606 conditions by eHealthMe. Check the latest studies of Hyperacusis.



On Apr, 05, 2026

180,723 people reported to have side effects when taking Morphine.
Among them, 33 people (0.02%) have Hyperacusis.

Could Morphine cause Hyperacusis?

Among these 33 people:

How long have people been on Morphine when they have Hyperacusis? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hyperacusis when taking Morphine? *

  • female: 61.29 %
  • male: 38.71 %

What is the age of people who have Hyperacusis when taking Morphine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 4 %
  • 20-29: 0.0 %
  • 30-39: 8 %
  • 40-49: 20 %
  • 50-59: 12 %
  • 60+: 56 %

What are other drugs people take besides Morphine? *

  1. Miralax: 10 people, 30.30%
  2. Xyrem: 10 people, 30.30%
  3. Ritalin: 9 people, 27.27%
  4. Cymbalta: 9 people, 27.27%
  5. Vitamin D3: 8 people, 24.24%
  6. Adderall: 7 people, 21.21%
  7. Vitamin B12: 7 people, 21.21%
  8. Dilantin: 6 people, 18.18%
  9. Clonazepam: 5 people, 15.15%
  10. Ofev: 5 people, 15.15%

What are other side effects people have besides Hyperacusis? *

  1. Fatigue (feeling of tiredness): 18 people, 54.55%
  2. Headache (pain in head): 14 people, 42.42%
  3. Vision Blurred: 12 people, 36.36%
  4. High Blood Pressure: 11 people, 33.33%
  5. Stress And Anxiety: 11 people, 33.33%
  6. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 10 people, 30.30%
  7. Dyspnea (difficult or laboured breathing): 10 people, 30.30%
  8. Feeling Abnormal: 10 people, 30.30%
  9. Depression: 10 people, 30.30%
  10. Tinnitus (a ringing in the ears): 9 people, 27.27%

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 30.30%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 15.15%
  3. Idiopathic Pulmonary Fibrosis (chronic lung disease): 5 people, 15.15%
  4. Depression: 4 people, 12.12%
  5. Headache (pain in head): 4 people, 12.12%
  6. Hiv Infection: 3 people, 9.09%
  7. Drowsiness: 3 people, 9.09%
  8. Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 9.09%
  9. Autoimmune Disorder (a condition in which the immune system attacks the body's normal substances and tissue): 2 people, 6.06%
  10. Constipation: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Morphine and have Hyperacusis?

- Check whether Hyperacusis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Morphine:

Hyperacusis treatments and more:

How severe was Hyperacusis and when was it recovered:

Expand to all the drugs that have ingredients of morphine sulfate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Morphine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperacusis:

Browse all the conditions that are associated with Hyperacusis:

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate (the active ingredients of Morphine) and Morphine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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