Morphine and Macule - a phase IV clinical study of FDA data

Summary:

Macule is reported as a side effect among people who take Morphine (morphine sulfate), especially for people who are female, 40-49 old, also take Otezla, and have Psoriasis.

The phase IV clinical study analyzes which people have Macule when taking Morphine. It is created by eHealthMe based on reports of 180,723 people who have side effects when taking Morphine from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,913 Morphine users. Check the latest studies of Morphine.

What is Macule?

Macule (a discoloured spot on the skin) is found to be associated with 315 drugs and 697 conditions by eHealthMe. Check the latest studies of Macule.

On Dec, 29, 2025

180,723 people reported to have side effects when taking Morphine.
Among them, 16 people (0.01%) have Macule.

Among these 16 people:

What is the gender of people who have Macule when taking Morphine? *

female: 100 %
male: 0.0 %

What is the age of people who have Macule when taking Morphine? *

What are other drugs people take besides Morphine? *

What are other side effects people have besides Macule? *

Rashes (redness): 13 people, 81.25%
Fatigue (feeling of tiredness): 13 people, 81.25%
Psoriasis (immune-mediated disease that affects the skin): 11 people, 68.75%
Haematemesis (vomiting of blood): 10 people, 62.50%
Oral Disorder (mouth disease): 10 people, 62.50%
Malaise (a feeling of general discomfort or uneasiness): 7 people, 43.75%
Pain In Extremity: 6 people, 37.50%
Itching: 5 people, 31.25%
Injection Site Pain: 4 people, 25.00%
Drug Hypersensitivity: 4 people, 25.00%

What are the existing conditions these people have? *

Ankylosing Spondylitis (type of arthritis affecting the spine): 10 people, 62.50%
Psoriasis (immune-mediated disease that affects the skin): 10 people, 62.50%
Hypotension (abnormally low blood pressure): 1 person, 6.25%
Bleeding Disorders: 1 person, 6.25%
Conjunctivitis (pink eye): 1 person, 6.25%
Cytomegalovirus Infection: 1 person, 6.25%
Depression: 1 person, 6.25%
Fungal Infection: 1 person, 6.25%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 1 person, 6.25%
Hyperkalemia (damage to or disease of the kidney): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Morphine and have Macule?

- Check whether Macule is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Morphine:

Morphine (182,913 reports)

Macule treatments and more:

Macule (3,263 reports)

Browse all side effects of Morphine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Macule:

Macule (315 drugs)

Browse all the conditions that are associated with Macule:

Macule (697 conditions)

Related publications that referenced our studies

Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate (the active ingredients of Morphine) and Morphine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.