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Morphine and Polymyalgia rheumatica - a phase IV clinical study of FDA data

Summary:

Polymyalgia rheumatica is reported as a side effect among people who take Morphine (morphine sulfate), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Prednisone, and have Metastases to bone.

The phase IV clinical study analyzes which people have Polymyalgia rheumatica when taking Morphine. It is created by eHealthMe based on reports of 180,723 people who have side effects when taking Morphine from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,914 Morphine users. Check the latest studies of Morphine.

What is Polymyalgia rheumatica?

Polymyalgia rheumatica (pain in many muscles) is found to be associated with 381 drugs and 554 conditions by eHealthMe. Check the latest studies of Polymyalgia rheumatica.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

180,723 people reported to have side effects when taking Morphine.
Among them, 28 people (0.02%) have Polymyalgia rheumatica.

Could Morphine cause Polymyalgia rheumatica?

Among these 28 people:

How long have people been on Morphine when they have Polymyalgia rheumatica? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Polymyalgia rheumatica when taking Morphine? *

  • female: 78.57 %
  • male: 21.43 %

What is the age of people who have Polymyalgia rheumatica when taking Morphine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 3.57 %
  • 30-39: 3.57 %
  • 40-49: 3.57 %
  • 50-59: 35.71 %
  • 60+: 53.57 %

What are other drugs people take besides Morphine? *

  1. Prednisone: 16 people, 57.14%
  2. Fosamax: 15 people, 53.57%
  3. Zoloft: 14 people, 50.00%
  4. Synthroid: 12 people, 42.86%
  5. Taxol: 10 people, 35.71%
  6. Herceptin: 10 people, 35.71%
  7. Aranesp: 10 people, 35.71%
  8. Aredia: 10 people, 35.71%
  9. Relafen: 10 people, 35.71%
  10. Navelbine: 10 people, 35.71%

What are other side effects people have besides Polymyalgia rheumatica? *

  1. Weight Decreased: 18 people, 64.29%
  2. Dyspnea (difficult or laboured breathing): 17 people, 60.71%
  3. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 16 people, 57.14%
  4. Weakness: 14 people, 50.00%
  5. Malaise (a feeling of general discomfort or uneasiness): 13 people, 46.43%
  6. Jaw Disorder (jaw disease): 12 people, 42.86%
  7. Spinal Osteoarthritis (joint cartilage loss in spine): 12 people, 42.86%
  8. Nausea (feeling of having an urge to vomit): 12 people, 42.86%
  9. Osteopenia (a condition where bone mineral density is lower than normal): 12 people, 42.86%
  10. Osteonecrosis Of Jaw (death of bone of jaw): 12 people, 42.86%

What are the existing conditions these people have? *

  1. Breast Cancer: 10 people, 35.71%
  2. Metastases To Bone (cancer spreads to bone): 10 people, 35.71%
  3. Depression: 7 people, 25.00%
  4. Asthma: 4 people, 14.29%
  5. Muscle Spasms (muscle contraction): 2 people, 7.14%
  6. Toothaches (tooth pain): 2 people, 7.14%
  7. Allergies: 2 people, 7.14%
  8. Osteoporosis (bones weak and more likely to break): 2 people, 7.14%
  9. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 7.14%
  10. Vasculitis (inflammation of a blood vessel or blood vessels): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Morphine and have Polymyalgia rheumatica?

- Check whether Polymyalgia rheumatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Morphine:

Polymyalgia rheumatica treatments and more:

How severe was Polymyalgia rheumatica and when was it recovered:

Expand to all the drugs that have ingredients of morphine sulfate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Morphine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Polymyalgia rheumatica:

Browse all the conditions that are associated with Polymyalgia rheumatica:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate (the active ingredients of Morphine) and Morphine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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