Morphine and Sleeping difficulty - a phase IV clinical study of FDA data

Summary:

Sleeping difficulty is reported as a side effect among people who take Morphine (morphine sulfate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Celebrex, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Sleeping difficulty when taking Morphine. It is created by eHealthMe based on reports of 180,723 people who have side effects when taking Morphine from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,913 Morphine users. Check the latest studies of Morphine.

What is Sleeping difficulty?

Sleeping difficulty (difficult sleeping) is found to be associated with 4,199 drugs and 5,350 conditions by eHealthMe. Check the latest studies of Sleeping difficulty.



On Oct, 17, 2025

180,723 people reported to have side effects when taking Morphine.
Among them, 4,024 people (2.23%) have Sleeping difficulty.

Could Morphine cause Sleeping difficulty?

Among these 4,024 people:

How long have people been on Morphine when they have Sleeping difficulty? *

What is the gender of people who have Sleeping difficulty when taking Morphine? *

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What is the age of people who have Sleeping difficulty when taking Morphine? *

What are other drugs people take besides Morphine? *

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What are other side effects people have besides Sleeping difficulty? *

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What are the existing conditions these people have? *

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* Approximation only. Some reports may have incomplete information.

Do you take Morphine and have Sleeping difficulty?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Morphine:

Sleeping difficulty treatments and more:

How severe was Sleeping difficulty and when was it recovered:

Expand to all the drugs that have ingredients of morphine sulfate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Morphine side effects:

Browse all side effects of Morphine:

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Common drugs associated with Sleeping difficulty:

Browse all the drugs that are associated with Sleeping difficulty:

Common conditions associated with Sleeping difficulty:

Browse all the conditions that are associated with Sleeping difficulty:

Drugs similar to Morphine and Sleeping difficulty :

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate (the active ingredients of Morphine) and Morphine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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