Morphine and Small intestinal perforation - a phase IV clinical study of FDA data

Summary:

Small intestinal perforation is reported as a side effect among people who take Morphine (morphine sulfate), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Acetaminophen, and have Crohn's disease.

The phase IV clinical study analyzes which people have Small intestinal perforation when taking Morphine. It is created by eHealthMe based on reports of 180,723 people who have side effects when taking Morphine from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,913 Morphine users. Check the latest studies of Morphine.

What is Small intestinal perforation?

Small intestinal perforation (hole in small intestine) is found to be associated with 232 drugs and 422 conditions by eHealthMe. Check the latest studies of Small intestinal perforation.

On Jul, 03, 2026

180,723 people reported to have side effects when taking Morphine.
Among them, 44 people (0.02%) have Small intestinal perforation.

Could Morphine cause Small intestinal perforation?

Among these 44 people:

How long have people been on Morphine when they have Small intestinal perforation? *

What is the gender of people who have Small intestinal perforation when taking Morphine? *

female: 51.16 %
male: 48.84 %

What is the age of people who have Small intestinal perforation when taking Morphine? *

What are other drugs people take besides Morphine? *

What are other side effects people have besides Small intestinal perforation? *

Drug Ineffective: 11 people, 25.00%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 10 people, 22.73%
Klebsiella Infection: 9 people, 20.45%
Gangrene (body tissue dies): 9 people, 20.45%
Abdominal Sepsis (abdominal infection): 9 people, 20.45%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 9 people, 20.45%
Nausea And Vomiting: 9 people, 20.45%
Hypoxic-Ischaemic Encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total): 9 people, 20.45%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 9 people, 20.45%
Blood Lactate Dehydrogenase Increased: 8 people, 18.18%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 12 people, 27.27%
Burkitt's Lymphoma (cancer of the lymphatic system): 8 people, 18.18%
Metastatic Gastric Cancer (cancer types can spread to the stomach from other place): 7 people, 15.91%
Constipation: 6 people, 13.64%
Rectal Cancer Metastatic (cancer of rectum spreads to other): 5 people, 11.36%
Stress And Anxiety: 2 people, 4.55%
Gastric Disorder (disease of stomach): 2 people, 4.55%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 2.27%
Cancer Pain: 1 person, 2.27%
Cervix Carcinoma (cancer of cervix): 1 person, 2.27%

* Approximation only. Some reports may have incomplete information.

Do you take Morphine and have Small intestinal perforation?

- Check whether Small intestinal perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Morphine:

Morphine (182,913 reports)

Browse all side effects of Morphine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Small intestinal perforation:

Small intestinal perforation (232 drugs)

Browse all the conditions that are associated with Small intestinal perforation:

Small intestinal perforation (422 conditions)

Related publications that referenced our studies

Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate (the active ingredients of Morphine) and Morphine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.