Msm and Pain exacerbated - a phase IV clinical study of FDA data

Summary:

Pain exacerbated is reported as a side effect among people who take Msm (methylsulfonylmethane), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Vitamin D3, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Pain exacerbated when taking Msm. It is created by eHealthMe based on reports of 978 people who have side effects when taking Msm from the FDA, and is updated regularly.

What is Msm?

Msm has active ingredients of methylsulfonylmethane. It is often used in joint pain. eHealthMe is studying from 1,210 Msm users. Check the latest studies of Msm.

What is Pain exacerbated?

Pain exacerbated is found to be associated with 3,987 drugs and 3,017 conditions by eHealthMe. Check the latest studies of Pain exacerbated.

On Jul, 10, 2026

978 people reported to have side effects when taking Msm.
Among them, 95 people (9.71%) have Pain exacerbated.

Among these 95 people:

How long have people been on Msm when they have Pain exacerbated? *

What is the gender of people who have Pain exacerbated when taking Msm? *

female: 76.92 %
male: 23.08 %

What is the age of people who have Pain exacerbated when taking Msm? *

What are other drugs people take besides Msm? *

What are other side effects people have besides Pain exacerbated? *

Drug Ineffective: 25 people, 26.32%
Fatigue (feeling of tiredness): 23 people, 24.21%
Fall: 19 people, 20.00%
High Blood Pressure: 17 people, 17.89%
Dizziness: 15 people, 15.79%
Nausea (feeling of having an urge to vomit): 14 people, 14.74%
Joint Swelling: 14 people, 14.74%
Insomnia (sleeplessness): 14 people, 14.74%
Itching: 13 people, 13.68%
Burning Sensation: 13 people, 13.68%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 26 people, 27.37%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 17.89%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 9.47%
Hypersensitivity: 8 people, 8.42%
Muscle Aches (muscle pain): 7 people, 7.37%
Asthma: 7 people, 7.37%
Stress And Anxiety: 7 people, 7.37%
Cystitis Interstitial (unknown cause characterized by bladder pain): 6 people, 6.32%
Back Pain: 6 people, 6.32%
Hormone Level Abnormal: 6 people, 6.32%

* Approximation only. Some reports may have incomplete information.

Do you take Msm and have Pain exacerbated?

- Check whether Pain exacerbated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Msm:

Msm (1,210 reports)

Browse all side effects of Msm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pain exacerbated:

Pain exacerbated (3,987 drugs)

Browse all the conditions that are associated with Pain exacerbated:

Pain exacerbated (3,017 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methylsulfonylmethane (the active ingredients of Msm) and Msm (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.