Naltrexone and Ankylosing spondylitis - a phase IV clinical study of FDA data

Summary:

Ankylosing spondylitis is reported as a side effect among people who take Naltrexone (naltrexone), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Escitalopram, and have Crohn's disease.

The phase IV clinical study analyzes which people have Ankylosing spondylitis when taking Naltrexone. It is created by eHealthMe based on reports of 4,805 people who have side effects when taking Naltrexone from the FDA, and is updated regularly.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,835 Naltrexone users. Check the latest studies of Naltrexone.

What is Ankylosing spondylitis?

Ankylosing spondylitis (type of arthritis affecting the spine) is found to be associated with 742 drugs and 1,051 conditions by eHealthMe. Check the latest studies of Ankylosing spondylitis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

4,805 people reported to have side effects when taking Naltrexone.
Among them, 23 people (0.48%) have Ankylosing spondylitis.

Could Naltrexone cause Ankylosing spondylitis?

Among these 23 people:

How long have people been on Naltrexone when they have Ankylosing spondylitis? *

What is the gender of people who have Ankylosing spondylitis when taking Naltrexone? *

female: 100 %
male: 0.0 %

What is the age of people who have Ankylosing spondylitis when taking Naltrexone? *

What are other drugs people take besides Naltrexone? *

What are other side effects people have besides Ankylosing spondylitis? *

Joint Pain: 15 people, 65.22%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 15 people, 65.22%
Weight Fluctuation: 11 people, 47.83%
Malaise (a feeling of general discomfort or uneasiness): 6 people, 26.09%
Sleep Apnea Syndrome: 5 people, 21.74%
High Blood Pressure: 4 people, 17.39%
Weight Increased: 3 people, 13.04%
Osteomalacia (softening of the bones due to a lack of vitamin d): 3 people, 13.04%
Peripheral Swelling: 2 people, 8.70%
Rickets (softening of bones): 2 people, 8.70%

What are the existing conditions these people have? *

Weight Decreased: 14 people, 60.87%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 14 people, 60.87%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 21.74%
Drowsiness: 2 people, 8.70%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 8.70%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 4.35%
Stress And Anxiety: 1 person, 4.35%
Sleep Disorder: 1 person, 4.35%
Rashes (redness): 1 person, 4.35%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Naltrexone and have Ankylosing spondylitis?

- Check whether Ankylosing spondylitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naltrexone:

Naltrexone (4,835 reports)

Browse all side effects of Naltrexone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ankylosing spondylitis:

Ankylosing spondylitis (742 drugs)

Browse all the conditions that are associated with Ankylosing spondylitis:

Ankylosing spondylitis (1,051 conditions)

Related publications that referenced our studies

Hung YM, Cheng CC, Wann SR, Lin SL, "Ankylosing spondylitis associated with pulmonary arterial hypertension", Internal Medicine, 2016 Jan .
Hung YM, Cheng CC, Wann SR, Lin SL, "Ankylosing spondylitis associated with pulmonary arterial hypertension", Internal Medicine, 2016 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on naltrexone (the active ingredients of Naltrexone) and Naltrexone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.