Narcan and Syncope - a phase IV clinical study of FDA data

Summary:

Syncope is reported as a side effect among people who take Narcan (naloxone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Furosemide, and have Pain.

The phase IV clinical study analyzes which people have Syncope when taking Narcan. It is created by eHealthMe based on reports of 3,672 people who have side effects when taking Narcan from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Syncope?

Syncope (loss of consciousness with an inability to maintain postural tone) is found to be associated with 3,503 drugs and 3,493 conditions by eHealthMe. Check the latest studies of Syncope.

On Dec, 04, 2025

3,672 people reported to have side effects when taking Narcan.
Among them, 38 people (1.03%) have Syncope.

Among these 38 people:

How long have people been on Narcan when they have Syncope? *

What is the gender of people who have Syncope when taking Narcan? *

female: 71.05 %
male: 28.95 %

What is the age of people who have Syncope when taking Narcan? *

What are other drugs people take besides Narcan? *

What are other side effects people have besides Syncope? *

Pain: 14 people, 36.84%
Stress And Anxiety: 13 people, 34.21%
Dyspnea (difficult or laboured breathing): 12 people, 31.58%
Weakness: 12 people, 31.58%
Fever: 11 people, 28.95%
Nausea (feeling of having an urge to vomit): 11 people, 28.95%
Hypotension (abnormally low blood pressure): 10 people, 26.32%
Insomnia (sleeplessness): 10 people, 26.32%
Nausea And Vomiting: 9 people, 23.68%
Depression: 9 people, 23.68%

What are the existing conditions these people have? *

Pain: 10 people, 26.32%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 15.79%
High Blood Pressure: 5 people, 13.16%
Metastases To Bone (cancer spreads to bone): 4 people, 10.53%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 7.89%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 7.89%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 7.89%
Oral Pain: 2 people, 5.26%
Dry Skin: 2 people, 5.26%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Narcan and have Syncope?

- Check whether Syncope is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Narcan:

Narcan (3,687 reports)

Syncope treatments and more:

Syncope (131,320 reports)

Browse all side effects of Narcan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Syncope:

Syncope (3,503 drugs)

Browse all the conditions that are associated with Syncope:

Syncope (3,493 conditions)

Related publications that referenced our studies

Dubrey SW, VanGriethuysen J, Edwards CM, "A hairy fall: syncope resulting from topical application of minoxidil", BMJ case reports, 2015 Sep .
Dubrey SW, VanGriethuysen J, Edwards CM, "A hairy fall: syncope resulting from topical application of minoxidil", BMJ case reports, 2015 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on naloxone hydrochloride (the active ingredients of Narcan) and Narcan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.