Naropin and Malaise - a phase IV clinical study of FDA data

Summary:

Malaise is reported as a side effect among people who take Naropin (ropivacaine hydrochloride monohydrate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Sufentanil Citrate, and have Local anaesthesia.

The phase IV clinical study analyzes which people have Malaise when taking Naropin. It is created by eHealthMe based on reports of 1,155 people who have side effects when taking Naropin from the FDA, and is updated regularly.

What is Naropin?

Naropin has active ingredients of ropivacaine hydrochloride monohydrate. eHealthMe is studying from 1,156 Naropin users. Check the latest studies of Naropin.

What is Malaise?

Malaise (a feeling of general discomfort or uneasiness) is found to be associated with 3,484 drugs and 5,129 conditions by eHealthMe. Check the latest studies of Malaise.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

1,155 people reported to have side effects when taking Naropin.
Among them, 12 people (1.04%) have Malaise.

Among these 12 people:

How long have people been on Naropin when they have Malaise? *

What is the gender of people who have Malaise when taking Naropin? *

female: 58.33 %
male: 41.67 %

What is the age of people who have Malaise when taking Naropin? *

What are other drugs people take besides Naropin? *

Sufentanil Citrate: 3 people, 25.00%
Xanax: 2 people, 16.67%
Syntocinon: 2 people, 16.67%
Carbocaine: 2 people, 16.67%
Xylocaine W/ Epinephrine: 1 person, 8.33%
Lovenox: 1 person, 8.33%
Aldomet: 1 person, 8.33%
Amlodipine: 1 person, 8.33%
Bupivacaine: 1 person, 8.33%
Cefazolin: 1 person, 8.33%

What are other side effects people have besides Malaise? *

Arrhythmias (irregular heartbeat): 3 people, 25.00%
Drug Toxicity: 3 people, 25.00%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 3 people, 25.00%
Hypotension (abnormally low blood pressure): 3 people, 25.00%
Acute Pulmonary Oedema (sudden deposit of fluid in the lung)): 2 people, 16.67%
Dyspnea (difficult or laboured breathing): 2 people, 16.67%
Cardiac Disorder: 2 people, 16.67%
Bradycardia Foetal (abnormally slow fetal heart rate, usually below 100 beats/min): 2 people, 16.67%
Troponin Increased: 2 people, 16.67%
Tonic Seizures (all the muscles to suddenly become stiff): 2 people, 16.67%

What are the existing conditions these people have? *

Local Anaesthesia: 2 people, 16.67%
Postpartum Haemorrhage (bleeding in woman after she has given birth): 1 person, 8.33%
Pain: 1 person, 8.33%
Neuroendocrine Tumor: 1 person, 8.33%
Gestational Hypertension (elevated blood pressure during pregnancy): 1 person, 8.33%
Epidural Anaesthesia: 1 person, 8.33%
Anaesthesia: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Naropin and have Malaise?

- Check whether Malaise is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naropin:

Naropin (1,156 reports)

Malaise treatments and more:

Malaise (529,933 reports)

How severe was Malaise and when was it recovered:

Malaise in Naropin

Expand to all the drugs that have ingredients of ropivacaine hydrochloride monohydrate:

Malaise and drugs with ingredients of ropivacaine hydrochloride monohydrate (16 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Naropin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malaise:

Malaise (3,484 drugs)

Browse all the conditions that are associated with Malaise:

Malaise (5,129 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ropivacaine hydrochloride monohydrate (the active ingredients of Naropin) and Naropin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.