Nexplanon and Chills - a phase IV clinical study of FDA data

Summary:

Chills is reported as a side effect among people who take Nexplanon (etonogestrel), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Vitamin D3, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Chills when taking Nexplanon. It is created by eHealthMe based on reports of 45,676 people who have side effects when taking Nexplanon from the FDA, and is updated regularly.

What is Nexplanon?

Nexplanon has active ingredients of etonogestrel. It is often used in birth control. eHealthMe is studying from 46,431 Nexplanon users. Check the latest studies of Nexplanon.

What is Chills?

Chills (felling of cold) is found to be associated with 2,551 drugs and 3,475 conditions by eHealthMe. Check the latest studies of Chills.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 26, 2026

45,676 people reported to have side effects when taking Nexplanon.
Among them, 48 people (0.11%) have Chills.

Among these 48 people:

How long have people been on Nexplanon when they have Chills? *

What is the gender of people who have Chills when taking Nexplanon? *

female: 100 %
male: 0.0 %

What is the age of people who have Chills when taking Nexplanon? *

What are other drugs people take besides Nexplanon? *

Vitamin D3: 7 people, 14.58%
Kesimpta: 6 people, 12.50%
Vitamin B12: 4 people, 8.33%
Klonopin: 4 people, 8.33%
Sertraline Hydrochloride: 4 people, 8.33%
Hydroxyzine Hydrochloride: 3 people, 6.25%
Gabapentin: 3 people, 6.25%
Prednisone: 2 people, 4.17%
Fish Oil: 2 people, 4.17%
Novolog: 2 people, 4.17%

What are other side effects people have besides Chills? *

Nausea (feeling of having an urge to vomit): 22 people, 45.83%
Fever: 16 people, 33.33%
Headache (pain in head): 14 people, 29.17%
Fatigue (feeling of tiredness): 10 people, 20.83%
Pain: 9 people, 18.75%
Dizziness: 8 people, 16.67%
Nausea And Vomiting: 7 people, 14.58%
Feeling Abnormal: 7 people, 14.58%
Weakness: 6 people, 12.50%
Dyspnea (difficult or laboured breathing): 5 people, 10.42%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 14.58%
Multiple Myeloma (cancer of the plasma cells): 2 people, 4.17%
Urinary Tract Infection: 1 person, 2.08%
Stress And Anxiety: 1 person, 2.08%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 2.08%
Polychondritis (progressive inflammation of cartilage and other connective tissue): 1 person, 2.08%
Iron Overload: 1 person, 2.08%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 2.08%
Depression: 1 person, 2.08%
Constipation: 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Do you take Nexplanon and have Chills?

- Check whether Chills is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nexplanon:

Nexplanon (46,431 reports)

Chills treatments and more:

Chills (145,628 reports)

Browse all side effects of Nexplanon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chills:

Chills (2,551 drugs)

Browse all the conditions that are associated with Chills:

Chills (3,475 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on etonogestrel (the active ingredients of Nexplanon) and Nexplanon (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.