Nexplanon and Middle insomnia - a phase IV clinical study of FDA data

Summary:

Middle insomnia is reported as a side effect among people who take Nexplanon (etonogestrel), especially for people who are female, 20-29 old, have been taking the drug for 6 - 12 months also take Vitamin D2, and have Asthma.

The phase IV clinical study analyzes which people have Middle insomnia when taking Nexplanon. It is created by eHealthMe based on reports of 45,676 people who have side effects when taking Nexplanon from the FDA, and is updated regularly.

What is Nexplanon?

Nexplanon has active ingredients of etonogestrel. It is often used in birth control. eHealthMe is studying from 46,431 Nexplanon users. Check the latest studies of Nexplanon.

What is Middle insomnia?

Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night) is found to be associated with 992 drugs and 969 conditions by eHealthMe. Check the latest studies of Middle insomnia.

On Jun, 17, 2026

45,676 people reported to have side effects when taking Nexplanon.
Among them, 12 people (0.03%) have Middle insomnia.

Among these 12 people:

How long have people been on Nexplanon when they have Middle insomnia? *

What is the gender of people who have Middle insomnia when taking Nexplanon? *

female: 100 %
male: 0.0 %

What is the age of people who have Middle insomnia when taking Nexplanon? *

What are other drugs people take besides Nexplanon? *

Wixela Inhub: 1 person, 8.33%
Lumryz: 1 person, 8.33%
Dupixent: 1 person, 8.33%
Escitalopram: 1 person, 8.33%
Evening Primrose Oil: 1 person, 8.33%
Imitrex: 1 person, 8.33%
Inh: 1 person, 8.33%
Lactobacillus Acidophilus: 1 person, 8.33%
Multivitamin: 1 person, 8.33%
Vitamin D2: 1 person, 8.33%

What are other side effects people have besides Middle insomnia? *

Pain In Extremity: 2 people, 16.67%
Ovarian Cyst Ruptured (tear in fluid filled sac of the ovary): 2 people, 16.67%
Fatigue (feeling of tiredness): 2 people, 16.67%
Nausea (feeling of having an urge to vomit): 2 people, 16.67%
Weight Increased: 1 person, 8.33%
Dysmenorrhea (painful menstruation): 1 person, 8.33%
Hyperhidrosis (abnormally increased sweating): 1 person, 8.33%
Hot Flush (sudden feelings of heat): 1 person, 8.33%
Hospitalisation: 1 person, 8.33%
Heavy Or Prolong Menstrual Bleeding: 1 person, 8.33%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 8.33%
Asthma: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Nexplanon and have Middle insomnia?

- Check whether Middle insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nexplanon:

Nexplanon (46,431 reports)

Middle insomnia treatments and more:

Middle insomnia (21,951 reports)

Browse all side effects of Nexplanon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Middle insomnia:

Middle insomnia (992 drugs)

Browse all the conditions that are associated with Middle insomnia:

Middle insomnia (969 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on etonogestrel (the active ingredients of Nexplanon) and Nexplanon (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.