Nicotine and Metabolic encephalopathy - a phase IV clinical study of FDA data

Summary:

Metabolic encephalopathy is reported as a side effect among people who take Nicotine (nicotine), especially for people who are male, 50-59 old, also take Spironolactone, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Metabolic encephalopathy when taking Nicotine. It is created by eHealthMe based on reports of 20,079 people who have side effects when taking Nicotine from the FDA, and is updated regularly.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

What is Metabolic encephalopathy?

Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy) is found to be associated with 552 drugs and 587 conditions by eHealthMe. Check the latest studies of Metabolic encephalopathy.

On Jul, 09, 2026

20,079 people reported to have side effects when taking Nicotine.
Among them, 15 people (0.07%) have Metabolic encephalopathy.

Could Nicotine cause Metabolic encephalopathy?

Among these 15 people:

What is the gender of people who have Metabolic encephalopathy when taking Nicotine? *

female: 6.67 %
male: 93.33 %

What is the age of people who have Metabolic encephalopathy when taking Nicotine? *

What are other drugs people take besides Nicotine? *

What are other side effects people have besides Metabolic encephalopathy? *

Hyperkalemia (damage to or disease of the kidney): 5 people, 33.33%
Renal Tubular Necrosis (death of kidney tubules): 4 people, 26.67%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 4 people, 26.67%
Anaemia (lack of blood): 4 people, 26.67%
Bleeding Disorders: 4 people, 26.67%
Weakness: 4 people, 26.67%
Systemic Inflammatory Response Syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection): 4 people, 26.67%
Electrolyte Imbalance: 4 people, 26.67%
Fatigue (feeling of tiredness): 3 people, 20.00%
Weight Decreased: 3 people, 20.00%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 26.67%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 13.33%
Neuropathy Peripheral (surface nerve damage): 2 people, 13.33%
Type 1 Diabetes: 1 person, 6.67%
Pain: 1 person, 6.67%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 6.67%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 6.67%
Lipodystrophy Acquired (a regional loss of subcutaneous adipose tissue which usually starts in the face, extends downward acquired): 1 person, 6.67%
Diarrhea: 1 person, 6.67%
Constipation: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Nicotine and have Metabolic encephalopathy?

- Check whether Metabolic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nicotine:

Nicotine (20,443 reports)

Browse all side effects of Nicotine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Metabolic encephalopathy:

Metabolic encephalopathy (552 drugs)

Browse all the conditions that are associated with Metabolic encephalopathy:

Metabolic encephalopathy (587 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nicotine (the active ingredients of Nicotine) and Nicotine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.