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Nicotine and Necrosis - a phase IV clinical study of FDA data

Summary:

Necrosis is reported as a side effect among people who take Nicotine (nicotine), especially for people who are female, 40-49 old, also take Morphine, and have Pain.

The phase IV clinical study analyzes which people have Necrosis when taking Nicotine. It is created by eHealthMe based on reports of 20,079 people who have side effects when taking Nicotine from the FDA, and is updated regularly.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

What is Necrosis?

Necrosis (the death of body tissue) is found to be associated with 760 drugs and 969 conditions by eHealthMe. Check the latest studies of Necrosis.

On Jul, 13, 2026

20,079 people reported to have side effects when taking Nicotine.
Among them, 22 people (0.11%) have Necrosis.

Could Nicotine cause Necrosis?

Among these 22 people:

What is the gender of people who have Necrosis when taking Nicotine? *

  • female: 55 %
  • male: 45 %

What is the age of people who have Necrosis when taking Nicotine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 30 %
  • 30-39: 5 %
  • 40-49: 50 %
  • 50-59: 5 %
  • 60+: 10 %

What are other drugs people take besides Nicotine? *

  1. Morphine: 12 people, 54.55%
  2. Benadryl: 9 people, 40.91%
  3. Ativan: 9 people, 40.91%
  4. Zopiclone: 9 people, 40.91%
  5. Imuran: 9 people, 40.91%
  6. Rituxan: 7 people, 31.82%
  7. Cymbalta: 5 people, 22.73%
  8. Vitamin C: 4 people, 18.18%
  9. Augmentin: 4 people, 18.18%
  10. Metformin: 4 people, 18.18%

What are other side effects people have besides Necrosis? *

  1. White Blood Cell Count Increased: 10 people, 45.45%
  2. Dyspnea (difficult or laboured breathing): 10 people, 45.45%
  3. Joint Pain: 10 people, 45.45%
  4. Hyperhidrosis (abnormally increased sweating): 10 people, 45.45%
  5. Fever: 10 people, 45.45%
  6. Fatigue (feeling of tiredness): 10 people, 45.45%
  7. Blood Pressure Fluctuation: 9 people, 40.91%
  8. Body Temperature Increased: 9 people, 40.91%
  9. Micturition Urgency (urgency to pass the urine): 9 people, 40.91%
  10. Malaise (a feeling of general discomfort or uneasiness): 9 people, 40.91%

What are the existing conditions these people have? *

  1. Sedation: 9 people, 40.91%
  2. Panic Disorder: 9 people, 40.91%
  3. Pain: 9 people, 40.91%
  4. Type 2 Diabetes: 5 people, 22.73%
  5. Weight Decreased: 3 people, 13.64%
  6. Hypotension (abnormally low blood pressure): 3 people, 13.64%
  7. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 4.55%
  8. Insomnia (sleeplessness): 1 person, 4.55%
  9. Drug Abuse: 1 person, 4.55%
  10. Agitation (state of anxiety or nervous excitement): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Nicotine and have Necrosis?

- Check whether Necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nicotine:

Necrosis treatments and more:

How severe was Necrosis and when was it recovered:

Expand to all the drugs that have ingredients of nicotine:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nicotine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Necrosis:

Browse all the conditions that are associated with Necrosis:

How the study uses the data?

The study uses data from the FDA. It is based on nicotine (the active ingredients of Nicotine) and Nicotine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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