Nitrofurantoin and Osteolysis - a phase IV clinical study of FDA data

Summary:

Osteolysis is reported as a side effect among people who take Nitrofurantoin (nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, also take Triamcinolone, and have Osteoporosis.

The phase IV clinical study analyzes which people have Osteolysis when taking Nitrofurantoin. It is created by eHealthMe based on reports of 4,140 people who have side effects when taking Nitrofurantoin from the FDA, and is updated regularly.

What is Nitrofurantoin?

Nitrofurantoin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 4,837 Nitrofurantoin users. Check the latest studies of Nitrofurantoin.

What is Osteolysis?

Osteolysis (dissolution of bone) is found to be associated with 689 drugs and 407 conditions by eHealthMe. Check the latest studies of Osteolysis.

On Jul, 17, 2026

4,140 people reported to have side effects when taking Nitrofurantoin.
Among them, 27 people (0.65%) have Osteolysis.

Among these 27 people:

What is the gender of people who have Osteolysis when taking Nitrofurantoin? *

female: 96.3 %
male: 3.7 %

What is the age of people who have Osteolysis when taking Nitrofurantoin? *

What are other drugs people take besides Nitrofurantoin? *

What are other side effects people have besides Osteolysis? *

Pain: 27 people, 100.00%
Fall: 26 people, 96.30%
Bone Disorder: 26 people, 96.30%
Hypophagia (reduced food intake): 25 people, 92.59%
Spinal Osteoarthritis (joint cartilage loss in spine): 25 people, 92.59%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 25 people, 92.59%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 25 people, 92.59%
Emotional Distress: 25 people, 92.59%
Pain In Jaw: 25 people, 92.59%
Dyspnea (difficult or laboured breathing): 25 people, 92.59%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 25 people, 92.59%
Trismus (reduced opening of the jaws): 1 person, 3.70%
Metastases To Bone (cancer spreads to bone): 1 person, 3.70%
Breast Cancer Metastatic: 1 person, 3.70%
B Precursor Type Acute Leukaemia (lymphoid cancer): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Nitrofurantoin and have Osteolysis?

- Check whether Osteolysis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nitrofurantoin:

Nitrofurantoin (4,837 reports)

Osteolysis treatments and more:

Osteolysis (4,092 reports)

How severe was Osteolysis and when was it recovered:

Osteolysis in Nitrofurantoin

Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:

Osteolysis and drugs with ingredients of nitrofurantoin, macrocrystalline

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nitrofurantoin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteolysis:

Osteolysis (689 drugs)

Browse all the conditions that are associated with Osteolysis:

Osteolysis (407 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Nitrofurantoin) and Nitrofurantoin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.