Norco and Brain herniation - a phase IV clinical study of FDA data

Summary:

Brain herniation is reported as a side effect among people who take Norco (acetaminophen; hydrocodone bitartrate), especially for people who are male, 50-59 old, also take Lexapro, and have Indigestion.

The phase IV clinical study analyzes which people have Brain herniation when taking Norco. It is created by eHealthMe based on reports of 71,619 people who have side effects when taking Norco from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Brain herniation?

Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull) is found to be associated with 337 drugs and 975 conditions by eHealthMe. Check the latest studies of Brain herniation.

On Jul, 22, 2026

71,619 people reported to have side effects when taking Norco.
Among them, 12 people (0.02%) have Brain herniation.

Among these 12 people:

What is the gender of people who have Brain herniation when taking Norco? *

female: 25 %
male: 75 %

What is the age of people who have Brain herniation when taking Norco? *

What are other drugs people take besides Norco? *

What are other side effects people have besides Brain herniation? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 8 people, 66.67%
Confusional State: 7 people, 58.33%
Headache (pain in head): 7 people, 58.33%
Weakness: 6 people, 50.00%
Fall: 6 people, 50.00%
Nausea (feeling of having an urge to vomit): 6 people, 50.00%
Muscle Spasms (muscle contraction): 6 people, 50.00%
Mucosal Inflammation (infection of mucous membrane): 6 people, 50.00%
Loose Tooth: 6 people, 50.00%
Leukopenia (less number of white blood cells in blood): 6 people, 50.00%

What are the existing conditions these people have? *

Urinary Tract Infection: 1 person, 8.33%
Headache (pain in head): 1 person, 8.33%
Cough: 1 person, 8.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 8.33%
Fatigue (feeling of tiredness): 1 person, 8.33%
Gastric Disorder (disease of stomach): 1 person, 8.33%
Gastric Ulcer (stomach ulcer): 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%
Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 1 person, 8.33%
Indigestion: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Norco and have Brain herniation?

- Check whether Brain herniation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norco:

Norco (74,063 reports)

Brain herniation treatments and more:

Brain herniation (3,706 reports)

How severe was Brain herniation and when was it recovered:

Brain herniation in Norco

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Brain herniation and drugs with ingredients of acetaminophen; hydrocodone bitartrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Norco:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain herniation:

Brain herniation (337 drugs)

Browse all the conditions that are associated with Brain herniation:

Brain herniation (975 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Norco) and Norco (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.