Norco and Hyperaesthesia - a phase IV clinical study of FDA data

Summary:

Hyperaesthesia is reported as a side effect among people who take Norco (acetaminophen; hydrocodone bitartrate), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Lyrica, and have Muscle spasms.

The phase IV clinical study analyzes which people have Hyperaesthesia when taking Norco. It is created by eHealthMe based on reports of 71,619 people who have side effects when taking Norco from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,060 Norco users. Check the latest studies of Norco.

What is Hyperaesthesia?

Hyperaesthesia is found to be associated with 918 drugs and 909 conditions by eHealthMe. Check the latest studies of Hyperaesthesia.

On Nov, 09, 2025

71,619 people reported to have side effects when taking Norco.
Among them, 72 people (0.1%) have Hyperaesthesia.

Among these 72 people:

* Approximation only. Some reports may have incomplete information.

Do you take Norco and have Hyperaesthesia?

- Check whether Hyperaesthesia is associated with a drug or a condition (FREE)
- Predict drug outcomes for up to one year with AI (FREE)
- Get an AI agent to monitor your drugs continuously (FREE)

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norco:

Norco (74,060 reports)

Hyperaesthesia treatments and more:

Hyperaesthesia (10,827 reports)

How severe was Hyperaesthesia and when was it recovered:

Hyperaesthesia in Norco

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Hyperaesthesia and drugs with ingredients of acetaminophen; hydrocodone bitartrate (365 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Norco side effects:

Norco side effect: Death (11,511 reports)
Norco side effect: Drug dependence (5,161 reports)

Browse all side effects of Norco:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Hyperaesthesia:

Browse all the drugs that are associated with Hyperaesthesia:

Hyperaesthesia (918 drugs)

Common conditions associated with Hyperaesthesia:

Pain: 868 reports
Ms: 761 reports
Ra: 742 reports
Acupuncture and pain: 378 reports
Hypertension aggravated: 371 reports
High blood pressure: 370 reports
Depression: 304 reports
Antidepressant therapy: 303 reports
Blood cholesterol abnormal: 258 reports
Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 230 reports

Browse all the conditions that are associated with Hyperaesthesia:

Hyperaesthesia (909 conditions)

Drugs similar to Norco and Hyperaesthesia :

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Norco) and Norco (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.