Norco and Raynaud's phenomenon - a phase IV clinical study of FDA data

Summary:

Raynaud's phenomenon is reported as a side effect among people who take Norco (acetaminophen; hydrocodone bitartrate), especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months also take Sonata, and have Narcolepsy.

The phase IV clinical study analyzes which people have Raynaud's phenomenon when taking Norco. It is created by eHealthMe based on reports of 71,619 people who have side effects when taking Norco from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Raynaud's phenomenon?

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas) is found to be associated with 628 drugs and 996 conditions by eHealthMe. Check the latest studies of Raynaud's phenomenon.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

71,619 people reported to have side effects when taking Norco.
Among them, 76 people (0.11%) have Raynaud's phenomenon.

Among these 76 people:

How long have people been on Norco when they have Raynaud's phenomenon? *

What is the gender of people who have Raynaud's phenomenon when taking Norco? *

female: 77.33 %
male: 22.67 %

What is the age of people who have Raynaud's phenomenon when taking Norco? *

What are other drugs people take besides Norco? *

What are other side effects people have besides Raynaud's phenomenon? *

Intervertebral Disc Protrusion (spinal disc protrusion): 37 people, 48.68%
Dyspnea (difficult or laboured breathing): 37 people, 48.68%
High Blood Pressure: 36 people, 47.37%
Depression: 31 people, 40.79%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 31 people, 40.79%
Facet Joint Syndrome (problem with movement of the facet joints of the spine): 31 people, 40.79%
Muscle Strain (an injury to a muscle in which the muscle fibres tear): 31 people, 40.79%
Insomnia (sleeplessness): 30 people, 39.47%
Hypoaesthesia (reduced sense of touch or sensation): 28 people, 36.84%
Hair Loss: 28 people, 36.84%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 21 people, 27.63%
Osteoporosis (bones weak and more likely to break): 16 people, 21.05%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 19.74%
Hepatitis C: 9 people, 11.84%
Drowsiness: 4 people, 5.26%
Stress And Anxiety: 3 people, 3.95%
Muscle Spasms (muscle contraction): 3 people, 3.95%
Nausea (feeling of having an urge to vomit): 2 people, 2.63%
Muscle Aches (muscle pain): 2 people, 2.63%
Post-Traumatic Stress Disorder: 2 people, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Norco and have Raynaud's phenomenon?

- Check whether Raynaud's phenomenon is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norco:

Norco (74,063 reports)

Raynaud's phenomenon treatments and more:

Raynaud's phenomenon (9,184 reports)

How severe was Raynaud's phenomenon and when was it recovered:

Raynaud's phenomenon in Norco

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Raynaud's phenomenon and drugs with ingredients of acetaminophen; hydrocodone bitartrate (185 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Norco:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Raynaud's phenomenon:

Raynaud's phenomenon (628 drugs)

Browse all the conditions that are associated with Raynaud's phenomenon:

Raynaud's phenomenon (996 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Norco) and Norco (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.