Norpace and Malaise - a phase IV clinical study of FDA data

Summary:

Malaise is reported as a side effect among people who take Norpace (disopyramide phosphate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Synthroid, and have Hypertrophic cardiomyopathy.

The phase IV clinical study analyzes which people have Malaise when taking Norpace. It is created by eHealthMe based on reports of 1,146 people who have side effects when taking Norpace from the FDA, and is updated regularly.

What is Norpace?

Norpace has active ingredients of disopyramide phosphate. eHealthMe is studying from 1,179 Norpace users. Check the latest studies of Norpace.

What is Malaise?

Malaise (a feeling of general discomfort or uneasiness) is found to be associated with 3,527 drugs and 5,118 conditions by eHealthMe. Check the latest studies of Malaise.

On Jul, 10, 2026

1,146 people reported to have side effects when taking Norpace.
Among them, 51 people (4.45%) have Malaise.

Among these 51 people:

How long have people been on Norpace when they have Malaise? *

What is the gender of people who have Malaise when taking Norpace? *

female: 90.2 %
male: 9.8 %

What is the age of people who have Malaise when taking Norpace? *

What are other drugs people take besides Norpace? *

What are other side effects people have besides Malaise? *

Weight Decreased: 8 people, 15.69%
Stress And Anxiety: 8 people, 15.69%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 7 people, 13.73%
Weight Increased: 6 people, 11.76%
Drug Ineffective: 6 people, 11.76%
Drug Intolerance (drug sensitivity): 6 people, 11.76%
Eye Disorder: 6 people, 11.76%
Memory Loss: 6 people, 11.76%
Nausea (feeling of having an urge to vomit): 6 people, 11.76%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 9.80%

What are the existing conditions these people have? *

Hypertrophic Cardiomyopathy (a condition in which the heart muscle becomes abnormally thick): 16 people, 31.37%
Cardiac Disorder: 13 people, 25.49%
High Blood Pressure: 11 people, 21.57%
Arrhythmias (irregular heartbeat): 10 people, 19.61%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 15.69%
Enlarged Heart: 7 people, 13.73%
Thyroid Diseases: 5 people, 9.80%
Mitral Valve Prolapse (heart's mitral valve doesn't work well): 5 people, 9.80%
Mitral Valve Incompetence (inefficient heart valve): 5 people, 9.80%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 9.80%

* Approximation only. Some reports may have incomplete information.

Do you take Norpace and have Malaise?

- Check whether Malaise is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norpace:

Norpace (1,179 reports)

Malaise treatments and more:

Malaise (529,933 reports)

Browse all side effects of Norpace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malaise:

Malaise (3,527 drugs)

Browse all the conditions that are associated with Malaise:

Malaise (5,118 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on disopyramide phosphate (the active ingredients of Norpace) and Norpace (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.