Northera and Irritability - a phase IV clinical study of FDA data

Summary:

Irritability is reported as a side effect among people who take Northera (droxidopa), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Valium, and have Orthostatic hypotension.

The phase IV clinical study analyzes which people have Irritability when taking Northera. It is created by eHealthMe based on reports of 22,868 people who have side effects when taking Northera from the FDA, and is updated regularly.

What is Northera?

Northera has active ingredients of droxidopa. eHealthMe is studying from 22,874 Northera users. Check the latest studies of Northera.

What is Irritability?

Irritability is found to be associated with 1,695 drugs and 2,463 conditions by eHealthMe. Check the latest studies of Irritability.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

22,868 people reported to have side effects when taking Northera.
Among them, 41 people (0.18%) have Irritability.

Among these 41 people:

How long have people been on Northera when they have Irritability? *

What is the gender of people who have Irritability when taking Northera? *

female: 47.22 %
male: 52.78 %

What is the age of people who have Irritability when taking Northera? *

What are other drugs people take besides Northera? *

What are other side effects people have besides Irritability? *

Headache (pain in head): 11 people, 26.83%
Fatigue (feeling of tiredness): 8 people, 19.51%
Dizziness: 8 people, 19.51%
Confusional State: 7 people, 17.07%
Agitation (state of anxiety or nervous excitement): 7 people, 17.07%
Stress And Anxiety: 7 people, 17.07%
Drowsiness: 6 people, 14.63%
Weakness: 6 people, 14.63%
Feeling Abnormal: 6 people, 14.63%
Nausea (feeling of having an urge to vomit): 5 people, 12.20%

What are the existing conditions these people have? *

Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 25 people, 60.98%
Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 11 people, 26.83%
Parkinson's Disease: 9 people, 21.95%
Fainting (loss of consciousness and postural tone): 5 people, 12.20%
Dizziness: 5 people, 12.20%
Autonomic Nervous System Imbalance (autonomic nervous system is of net equal emphasis): 4 people, 9.76%
Autonomic Failure Syndrome (a degenerative disease of the autonomic nervous system): 2 people, 4.88%
Stress And Anxiety: 1 person, 2.44%
Postural Orthostatic Tachycardia Syndrome (abnormal increase in heart rate on becoming upright): 1 person, 2.44%
Neuropathy Peripheral (surface nerve damage): 1 person, 2.44%

* Approximation only. Some reports may have incomplete information.

Do you take Northera and have Irritability?

- Check whether Irritability is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Northera:

Northera (22,874 reports)

Irritability treatments and more:

Irritability (71,614 reports)

Browse all side effects of Northera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Irritability:

Irritability (1,695 drugs)

Browse all the conditions that are associated with Irritability:

Irritability (2,463 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on droxidopa (the active ingredients of Northera) and Northera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.