Novalgin and Bone density decreased - a phase IV clinical study of FDA data

Summary:

Bone density decreased is reported as a side effect among people who take Novalgin (metamizole), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Pantoprazole, and have Relapsing-remitting multiple sclerosis.

The phase IV clinical study analyzes which people have Bone density decreased when taking Novalgin. It is created by eHealthMe based on reports of 10,087 people who have side effects when taking Novalgin from the FDA, and is updated regularly.

What is Novalgin?

Novalgin has active ingredients of metamizole. It is often used in pain. eHealthMe is studying from 10,177 Novalgin users. Check the latest studies of Novalgin.

What is Bone density decreased?

Bone density decreased is found to be associated with 1,121 drugs and 949 conditions by eHealthMe. Check the latest studies of Bone density decreased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

10,087 people reported to have side effects when taking Novalgin.
Among them, 13 people (0.13%) have Bone density decreased.

Could Novalgin cause Bone density decreased?

Among these 13 people:

How long have people been on Novalgin when they have Bone density decreased? *

What is the gender of people who have Bone density decreased when taking Novalgin? *

female: 100 %
male: 0.0 %

What is the age of people who have Bone density decreased when taking Novalgin? *

What are other drugs people take besides Novalgin? *

Ibuprofen: 8 people, 61.54%
Pantoprazole: 8 people, 61.54%
Albuterol: 7 people, 53.85%
Ocrevus: 7 people, 53.85%
Folic Acid: 7 people, 53.85%
Oxycodone: 7 people, 53.85%
Triamcinolone Acetonide: 6 people, 46.15%
Ramipril: 4 people, 30.77%
Pantoprazole Sodium: 4 people, 30.77%
Cefuroxime: 3 people, 23.08%

What are other side effects people have besides Bone density decreased? *

Cataract (clouding of the lens inside the eye): 9 people, 69.23%
Weight Increased: 8 people, 61.54%
Weakness: 8 people, 61.54%
Vitamin D Decreased: 8 people, 61.54%
High Blood Pressure: 8 people, 61.54%
Osteoporosis (bones weak and more likely to break): 8 people, 61.54%
Nasopharyngitis (inflammation of the nasopharynx): 7 people, 53.85%
Fever: 7 people, 53.85%
Pain In Extremity: 7 people, 53.85%
Flatulence (flatus expelled through the anus): 7 people, 53.85%

What are the existing conditions these people have? *

Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 7 people, 53.85%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 7 people, 53.85%
Progressive Relapsing Multiple Sclerosis (chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord or both): 5 people, 38.46%
Osteoporosis (bones weak and more likely to break): 3 people, 23.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 23.08%
Urinary Tract Infection: 2 people, 15.38%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 15.38%
Nasopharyngitis (inflammation of the nasopharynx): 2 people, 15.38%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 15.38%
Joint Pain: 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Novalgin and have Bone density decreased?

- Check whether Bone density decreased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Novalgin:

Novalgin (10,177 reports)

Browse all side effects of Novalgin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone density decreased:

Bone density decreased (1,121 drugs)

Browse all the conditions that are associated with Bone density decreased:

Bone density decreased (949 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metamizole (the active ingredients of Novalgin) and Novalgin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.