Novolog and Brain death - a phase IV clinical study of FDA data

Summary:

Brain death is reported as a side effect among people who take Novolog (insulin aspart recombinant), especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years also take Lantus, and have Pain.

The study is created by eHealthMe based on reports of 55,653 people who have side effects when taking Novolog from the FDA, and is updated regularly.

What is Novolog?

Novolog has active ingredients of insulin aspart recombinant. It is often used in diabetes. eHealthMe is studying from 56,160 Novolog users. Check the latest studies of Novolog.

On Aug, 10, 2026

55,653 people reported to have side effects when taking Novolog.
Among them, 18 people (0.03%) died.

Among these 18 people:

How long have people been on Novolog when they died? *

What is the gender of people who died when taking Novolog? *

female: 17.65 %
male: 82.35 %

What is the age of people who died when taking Novolog? *

What are other drugs people take besides Novolog? *

Lantus: 11 people, 61.11%
Uroxatral: 7 people, 38.89%
Diprolene: 7 people, 38.89%
Cymbalta: 7 people, 38.89%
Warfarin Sodium: 7 people, 38.89%
Oxycontin: 7 people, 38.89%
Ammonium Lactate: 7 people, 38.89%
Ambien: 7 people, 38.89%
Hydrocodone Bitartrate And Acetaminophen: 5 people, 27.78%
Metoprolol Tartrate: 5 people, 27.78%

What are other side effects people have before they died? *

Malaise (a feeling of general discomfort or uneasiness): 8 people, 44.44%
Fall: 8 people, 44.44%
High Blood Pressure: 7 people, 38.89%
Haemorrhagic Stroke (stroke caused by the rupture of a blood vessel in the brain): 7 people, 38.89%
Breathing - Slowed Or Stopped: 7 people, 38.89%
Skin - Clammy: 7 people, 38.89%
Bleeding Disorders: 7 people, 38.89%
Cardiac Arrest: 6 people, 33.33%
Blood Pressure Abnormal: 5 people, 27.78%
Hypotension (abnormally low blood pressure): 5 people, 27.78%

What are the existing conditions these people have? *

Neuropathy Peripheral (surface nerve damage): 7 people, 38.89%
Insomnia (sleeplessness): 7 people, 38.89%
Micturition Disorder (disease of passing urine): 7 people, 38.89%
Pain: 7 people, 38.89%
Pain In Extremity: 4 people, 22.22%
Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 3 people, 16.67%
Feeling Of Relaxation: 3 people, 16.67%
Joint Pain: 3 people, 16.67%
Cystic Fibrosis (disease of the secretary glands): 3 people, 16.67%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 3 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Novolog:

Novolog (56,160 reports)

Expand to all the drugs that have ingredients of insulin aspart recombinant:

Brain death and drugs with ingredients of insulin aspart recombinant (23 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Novolog:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain death:

Brain death (315 drugs)

Browse all the conditions that are associated with Brain death:

Brain death (489 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on insulin aspart recombinant (the active ingredients of Novolog) and Novolog (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.