Nuvaring and Mitral valve prolapse - a phase IV clinical study of FDA data

Summary:

Mitral valve prolapse is reported as a side effect among people who take Nuvaring (ethinyl estradiol; etonogestrel), especially for people who are female, 30-39 old, have been taking the drug for 2 - 5 years also take Benadryl, and have Endometriosis.

The phase IV clinical study analyzes which people have Mitral valve prolapse when taking Nuvaring. It is created by eHealthMe based on reports of 27,664 people who have side effects when taking Nuvaring from the FDA, and is updated regularly.

What is Nuvaring?

Nuvaring has active ingredients of ethinyl estradiol; etonogestrel. It is often used in birth control. eHealthMe is studying from 28,730 Nuvaring users. Check the latest studies of Nuvaring.

What is Mitral valve prolapse?

Mitral valve prolapse (heart's mitral valve doesn't work well) is found to be associated with 505 drugs and 859 conditions by eHealthMe. Check the latest studies of Mitral valve prolapse.

On Jul, 13, 2026

27,664 people reported to have side effects when taking Nuvaring.
Among them, 72 people (0.26%) have Mitral valve prolapse.

Could Nuvaring cause Mitral valve prolapse?

Among these 72 people:

How long have people been on Nuvaring when they have Mitral valve prolapse? *

What is the gender of people who have Mitral valve prolapse when taking Nuvaring? *

female: 100 %
male: 0.0 %

What is the age of people who have Mitral valve prolapse when taking Nuvaring? *

What are other drugs people take besides Nuvaring? *

Advil Liqui-Gels: 10 people, 13.89%
Benadryl: 10 people, 13.89%
Allegra: 9 people, 12.50%
Effexor Xr: 9 people, 12.50%
Diazepam: 9 people, 12.50%
Cephalexin: 9 people, 12.50%
Lortab: 9 people, 12.50%
Hydrocodone Bitartrate And Acetaminophen: 8 people, 11.11%
Advil: 8 people, 11.11%
Tylenol: 6 people, 8.33%

What are other side effects people have besides Mitral valve prolapse? *

Pulmonary Embolism (blockage of the main artery of the lung): 44 people, 61.11%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 38 people, 52.78%
Depression: 36 people, 50.00%
Stress And Anxiety: 35 people, 48.61%
Arrhythmias (irregular heartbeat): 25 people, 34.72%
Dizziness: 24 people, 33.33%
Migraine (headache): 24 people, 33.33%
Chest Pain: 19 people, 26.39%
Nausea (feeling of having an urge to vomit): 19 people, 26.39%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 18 people, 25.00%

What are the existing conditions these people have? *

Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 3 people, 4.17%
Weight Loss: 2 people, 2.78%
Menstruation Irregular: 2 people, 2.78%
Heavy Or Prolong Menstrual Bleeding: 2 people, 2.78%
Menopausal Symptoms: 2 people, 2.78%
Weight Decreased: 2 people, 2.78%
Menstrual Disorder (disease of menstrual cycle): 2 people, 2.78%
Multiple Allergies (allergy to multiple agents): 1 person, 1.39%
Migraine (headache): 1 person, 1.39%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 1.39%

* Approximation only. Some reports may have incomplete information.

Do you take Nuvaring and have Mitral valve prolapse?

- Check whether Mitral valve prolapse is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nuvaring:

Nuvaring (28,730 reports)

Mitral valve prolapse treatments and more:

Mitral valve prolapse (5,125 reports)

How severe was Mitral valve prolapse and when was it recovered:

Mitral valve prolapse in Nuvaring

Expand to all the drugs that have ingredients of ethinyl estradiol; etonogestrel:

Mitral valve prolapse and drugs with ingredients of ethinyl estradiol; etonogestrel

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nuvaring:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mitral valve prolapse:

Mitral valve prolapse (505 drugs)

Browse all the conditions that are associated with Mitral valve prolapse:

Mitral valve prolapse (859 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; etonogestrel (the active ingredients of Nuvaring) and Nuvaring (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.