Odefsey and Oa - a phase IV clinical study of FDA data

Summary:

Oa is reported as a side effect among people who take Odefsey (emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate), especially for people who are male, 50-59 old, also take Atripla, and have Acquired immunodeficiency syndrome.

The phase IV clinical study analyzes which people have Oa when taking Odefsey. It is created by eHealthMe based on reports of 4,585 people who have side effects when taking Odefsey from the FDA, and is updated regularly.

What is Odefsey?

Odefsey has active ingredients of emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 4,605 Odefsey users. Check the latest studies of Odefsey.

What is Oa?

Oa (osteoarthritis /a joint disease caused by cartilage loss in a joint) is found to be associated with 1,894 drugs and 2,638 conditions by eHealthMe. Check the latest studies of Oa.

On Apr, 30, 2026

4,585 people reported to have side effects when taking Odefsey.
Among them, 98 people (2.14%) have Oa.

Among these 98 people:

What is the gender of people who have Oa when taking Odefsey? *

female: 36.73 %
male: 63.27 %

What is the age of people who have Oa when taking Odefsey? *

What are other drugs people take besides Odefsey? *

What are other side effects people have besides Oa? *

Bone Density Decreased: 72 people, 73.47%
Pain: 58 people, 59.18%
Emotional Distress: 57 people, 58.16%
Osteoporosis (bones weak and more likely to break): 54 people, 55.10%
Stress And Anxiety: 48 people, 48.98%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 45 people, 45.92%
Tooth Loss: 37 people, 37.76%
Bone Loss: 34 people, 34.69%
Chronic Kidney Disease: 34 people, 34.69%
Osteopenia (a condition where bone mineral density is lower than normal): 33 people, 33.67%

What are the existing conditions these people have? *

Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 15 people, 15.31%
Pain: 3 people, 3.06%
Stress And Anxiety: 2 people, 2.04%
Urinary Tract Infection: 1 person, 1.02%
High Blood Cholesterol: 1 person, 1.02%
Allergic Rhinitis: 1 person, 1.02%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 1.02%
Bacterial Infection: 1 person, 1.02%
Cough: 1 person, 1.02%
Depression: 1 person, 1.02%

* Approximation only. Some reports may have incomplete information.

Do you take Odefsey and have Oa?

- Check whether Oa is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Odefsey:

Odefsey (4,605 reports)

Oa treatments and more:

Oa (95,653 reports)

How severe was Oa and when was it recovered:

Oa in Odefsey

Expand to all the drugs that have ingredients of emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate:

Oa and drugs with ingredients of emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate (52 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Odefsey:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oa:

Oa (1,894 drugs)

Browse all the conditions that are associated with Oa:

Oa (2,638 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate (the active ingredients of Odefsey) and Odefsey (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.