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Ofev and Crohn's disease - a phase IV clinical study of FDA data

Summary:

Crohn's disease is reported as a side effect among people who take Ofev (nintedanib esylate), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Potassium, and have Idiopathic pulmonary fibrosis.

The phase IV clinical study analyzes which people have Crohn's disease when taking Ofev. It is created by eHealthMe based on reports of 24,754 people who have side effects when taking Ofev from the FDA, and is updated regularly.

What is Ofev?

Ofev has active ingredients of nintedanib esylate. eHealthMe is studying from 24,791 Ofev users. Check the latest studies of Ofev.

What is Crohn's disease?

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract) is found to be associated with 1,353 drugs and 2,072 conditions by eHealthMe. Check the latest studies of Crohn's disease.

On Jul, 16, 2026

24,754 people reported to have side effects when taking Ofev.
Among them, 13 people (0.05%) have Crohn's disease.

Could Ofev cause Crohn's disease?

Among these 13 people:

How long have people been on Ofev when they have Crohn's disease? *

  • < 1 month: 16.67 %
  • 1 - 6 months: 66.67 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 16.67 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Crohn's disease when taking Ofev? *

  • female: 76.92 %
  • male: 23.08 %

What is the age of people who have Crohn's disease when taking Ofev? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 7.69 %
  • 60+: 92.31 %

What are other drugs people take besides Ofev? *

  1. Potassium: 2 people, 15.38%
  2. Tyvaso Dpi: 1 person, 7.69%
  3. Synthroid: 1 person, 7.69%
  4. Spiriva: 1 person, 7.69%
  5. Norvasc: 1 person, 7.69%
  6. Imodium: 1 person, 7.69%
  7. Eliquis: 1 person, 7.69%
  8. Duoneb: 1 person, 7.69%
  9. Cozaar: 1 person, 7.69%
  10. Colace: 1 person, 7.69%

What are other side effects people have besides Crohn's disease? *

  1. Diarrhea: 11 people, 84.62%
  2. Abdominal Pain Upper: 9 people, 69.23%
  3. Weight Decreased: 9 people, 69.23%
  4. Pneumonia: 8 people, 61.54%
  5. Productive Cough: 8 people, 61.54%
  6. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 6 people, 46.15%
  7. Constipation: 6 people, 46.15%
  8. Nausea (feeling of having an urge to vomit): 6 people, 46.15%
  9. Stress And Anxiety: 5 people, 38.46%
  10. Rectal Haemorrhage (bleeding from anus): 5 people, 38.46%

What are the existing conditions these people have? *

  1. Idiopathic Pulmonary Fibrosis (chronic lung disease): 13 people, 100.00%
  2. Interstitial Lung Disease: 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Ofev and have Crohn's disease?

- Check whether Crohn's disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ofev:

  • Ofev (24,791 reports)

Crohn's disease treatments and more:

How severe was Crohn's disease and when was it recovered:

Expand to all the drugs that have ingredients of nintedanib esylate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ofev:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Crohn's disease:

Browse all the conditions that are associated with Crohn's disease:

How the study uses the data?

The study uses data from the FDA. It is based on nintedanib esylate (the active ingredients of Ofev) and Ofev (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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