Omeprazole and Sickle cell anemia - a phase IV clinical study of FDA data

Summary:

Sickle cell anemia is reported as a side effect among people who take Omeprazole (omeprazole), especially for people who are male, 40-49 old, also take Pepcid Ac, and have Pain.

The phase IV clinical study analyzes which people have Sickle cell anemia when taking Omeprazole. It is created by eHealthMe based on reports of 400,982 people who have side effects when taking Omeprazole from the FDA, and is updated regularly.

What is Omeprazole?

Omeprazole has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 410,631 Omeprazole users. Check the latest studies of Omeprazole.

What is Sickle cell anemia?

Sickle cell anemia (a disease in which your body produces abnormally shaped red blood cells) is found to be associated with 29 drugs and 22 conditions by eHealthMe. Check the latest studies of Sickle cell anemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

400,982 people reported to have side effects when taking Omeprazole.
Among them, 12 people (0.0%) have Sickle cell anemia.

Could Omeprazole cause Sickle cell anemia?

Among these 12 people:

What is the gender of people who have Sickle cell anemia when taking Omeprazole? *

female: 30 %
male: 70 %

What is the age of people who have Sickle cell anemia when taking Omeprazole? *

What are other drugs people take besides Omeprazole? *

What are other side effects people have besides Sickle cell anemia? *

Acute Kidney Failure: 5 people, 41.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 25.00%
Hospitalisation: 3 people, 25.00%
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung): 2 people, 16.67%
Back Pain: 2 people, 16.67%
Diarrhea: 2 people, 16.67%
Drowsiness: 2 people, 16.67%
Fatigue (feeling of tiredness): 2 people, 16.67%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 2 people, 16.67%
Joint Pain: 2 people, 16.67%

What are the existing conditions these people have? *

Pain: 7 people, 58.33%
Blood Pressure Abnormal: 5 people, 41.67%
Blood Phosphorus Abnormal: 5 people, 41.67%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 25.00%
Haemochromatosis (body to absorb more iron than usual from food): 2 people, 16.67%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 8.33%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Omeprazole and have Sickle cell anemia?

- Check whether Sickle cell anemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Omeprazole:

Omeprazole (410,631 reports)

Browse all side effects of Omeprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sickle cell anemia:

Sickle cell anemia (29 drugs)

Browse all the conditions that are associated with Sickle cell anemia:

Sickle cell anemia (22 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on omeprazole (the active ingredients of Omeprazole) and Omeprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.