Opana and Weight increased - a phase IV clinical study of FDA data

Summary:

Weight increased is reported as a side effect among people who take Opana (oxymorphone hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Percocet, and have Breakthrough pain.

The phase IV clinical study analyzes which people have Weight increased when taking Opana. It is created by eHealthMe based on reports of 39,845 people who have side effects when taking Opana from the FDA, and is updated regularly.

What is Opana?

Opana has active ingredients of oxymorphone hydrochloride. It is often used in pain. eHealthMe is studying from 40,340 Opana users. Check the latest studies of Opana.

What is Weight increased?

Weight increased is found to be associated with 2,888 drugs and 3,947 conditions by eHealthMe. Check the latest studies of Weight increased.

On Apr, 15, 2026

39,845 people reported to have side effects when taking Opana.
Among them, 89 people (0.22%) have Weight increased.

Among these 89 people:

How long have people been on Opana when they have Weight increased? *

What is the gender of people who have Weight increased when taking Opana? *

female: 57.95 %
male: 42.05 %

What is the age of people who have Weight increased when taking Opana? *

What are other drugs people take besides Opana? *

Percocet: 22 people, 24.72%
Oxycontin: 20 people, 22.47%
Dilaudid: 15 people, 16.85%
Lyrica: 15 people, 16.85%
Oxycodone: 13 people, 14.61%
Hydrocodone Bitartrate And Acetaminophen: 13 people, 14.61%
Cymbalta: 12 people, 13.48%
Flexeril: 7 people, 7.87%
Tramadol Hydrochloride: 6 people, 6.74%
Nexium: 6 people, 6.74%

What are other side effects people have besides Weight increased? *

Overdose: 19 people, 21.35%
Depression: 18 people, 20.22%
Drug Dependence: 18 people, 20.22%
Constipation: 16 people, 17.98%
Stress And Anxiety: 15 people, 16.85%
Memory Loss: 12 people, 13.48%
Drug Ineffective: 12 people, 13.48%
Joint Pain: 12 people, 13.48%
Oedema Peripheral (superficial swelling): 11 people, 12.36%
Nausea (feeling of having an urge to vomit): 11 people, 12.36%

What are the existing conditions these people have? *

Breakthrough Pain: 11 people, 12.36%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 10.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 6.74%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 5.62%
Stress And Anxiety: 5 people, 5.62%
Abdominal Pain: 4 people, 4.49%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 4.49%
Constipation: 4 people, 4.49%
Joint Pain: 4 people, 4.49%
Insomnia (sleeplessness): 3 people, 3.37%

* Approximation only. Some reports may have incomplete information.

Do you take Opana and have Weight increased?

- Check whether Weight increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Opana:

Opana (40,340 reports)

Weight increased treatments and more:

Weight increased (279,367 reports)

Browse all side effects of Opana:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight increased:

Weight increased (2,888 drugs)

Browse all the conditions that are associated with Weight increased:

Weight increased (3,947 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on oxymorphone hydrochloride (the active ingredients of Opana) and Opana (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.