Orenitram and Skin ulcer - a phase IV clinical study of FDA data

Summary:

Skin ulcer is reported as a side effect among people who take Orenitram (treprostinil), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Opsumit, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Skin ulcer when taking Orenitram. It is created by eHealthMe based on reports of 17,713 people who have side effects when taking Orenitram from the FDA, and is updated regularly.

What is Orenitram?

Orenitram has active ingredients of treprostinil. eHealthMe is studying from 17,714 Orenitram users. Check the latest studies of Orenitram.

What is Skin ulcer?

Skin ulcer is found to be associated with 1,452 drugs and 1,482 conditions by eHealthMe. Check the latest studies of Skin ulcer.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

17,713 people reported to have side effects when taking Orenitram.
Among them, 31 people (0.18%) have Skin ulcer.

Among these 31 people:

How long have people been on Orenitram when they have Skin ulcer? *

What is the gender of people who have Skin ulcer when taking Orenitram? *

female: 90.32 %
male: 9.68 %

What is the age of people who have Skin ulcer when taking Orenitram? *

What are other drugs people take besides Orenitram? *

What are other side effects people have besides Skin ulcer? *

Headache (pain in head): 13 people, 41.94%
Diarrhea: 12 people, 38.71%
Weight Decreased: 11 people, 35.48%
Nausea (feeling of having an urge to vomit): 11 people, 35.48%
Joint Pain: 9 people, 29.03%
Dyspnea (difficult or laboured breathing): 8 people, 25.81%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 8 people, 25.81%
Oedema (fluid collection in tissue): 8 people, 25.81%
Dizziness: 8 people, 25.81%
Oedema Peripheral (superficial swelling): 7 people, 22.58%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 26 people, 83.87%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 16.13%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 1 person, 3.23%
Parkinson's Disease: 1 person, 3.23%
Connective Tissue Disorder (any disease that has the connective tissues of the body): 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Orenitram and have Skin ulcer?

- Check whether Skin ulcer is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Orenitram:

Orenitram (17,714 reports)

Skin ulcer treatments and more:

Skin ulcer (33,745 reports)

Browse all side effects of Orenitram:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin ulcer:

Skin ulcer (1,452 drugs)

Browse all the conditions that are associated with Skin ulcer:

Skin ulcer (1,482 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on treprostinil (the active ingredients of Orenitram) and Orenitram (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.