Ortho tri-cyclen and Toothaches - a phase IV clinical study of FDA data

Summary:

Toothaches is reported as a side effect among people who take Ortho tri-cyclen (ethinyl estradiol; norgestimate), especially for people who are female, 10-19 old, also take Accutane, and have Depression.

The phase IV clinical study analyzes which people have Toothaches when taking Ortho tri-cyclen. It is created by eHealthMe based on reports of 4,840 people who have side effects when taking Ortho tri-cyclen from the FDA, and is updated regularly.

What is Ortho tri-cyclen?

Ortho tri-cyclen has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 5,699 Ortho tri-cyclen users. Check the latest studies of Ortho tri-cyclen.

What is Toothaches?

Toothaches (tooth pain) is found to be associated with 1,325 drugs and 1,605 conditions by eHealthMe. Check the latest studies of Toothaches.

On Jul, 11, 2026

4,840 people reported to have side effects when taking Ortho tri-cyclen.
Among them, 14 people (0.29%) have Toothaches.

Could Ortho tri-cyclen cause Toothaches?

Among these 14 people:

What is the gender of people who have Toothaches when taking Ortho tri-cyclen? *

female: 100 %
male: 0.0 %

What is the age of people who have Toothaches when taking Ortho tri-cyclen? *

What are other drugs people take besides Ortho tri-cyclen? *

What are other side effects people have besides Toothaches? *

Sinusitis (inflammation of sinus): 10 people, 71.43%
Abdominal Discomfort: 8 people, 57.14%
Inflammatory Bowel Disease: 8 people, 57.14%
Abdominal Distension: 8 people, 57.14%
Anal Fistula: 8 people, 57.14%
Cheilitis (infection of lips): 8 people, 57.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 8 people, 57.14%
Cuts And Puncture Wounds: 8 people, 57.14%
Dry Skin: 8 people, 57.14%
Facial Pain: 8 people, 57.14%

What are the existing conditions these people have? *

Sleep Disorder: 2 people, 14.29%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 14.29%
High Blood Cholesterol: 2 people, 14.29%
Depression: 2 people, 14.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.14%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Ortho tri-cyclen and have Toothaches?

- Check whether Toothaches is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ortho tri-cyclen:

Ortho tri-cyclen (5,699 reports)

Toothaches treatments and more:

Toothaches (28,231 reports)

How severe was Toothaches and when was it recovered:

Toothaches in Ortho tri-cyclen

Expand to all the drugs that have ingredients of ethinyl estradiol; norgestimate:

Toothaches and drugs with ingredients of ethinyl estradiol; norgestimate (24 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ortho tri-cyclen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Toothaches:

Toothaches (1,325 drugs)

Browse all the conditions that are associated with Toothaches:

Toothaches (1,605 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norgestimate (the active ingredients of Ortho tri-cyclen) and Ortho tri-cyclen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.