1. Home
  2. Analysis
  3. Oxbryta
  4. Agitation-aggravated

Oxbryta and Agitation aggravated - a phase IV clinical study of FDA data

Summary:

Agitation aggravated is reported as a side effect among people who take Oxbryta (voxelotor), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Oxycodone, and have Haemochromatosis.

The phase IV clinical study analyzes which people have Agitation aggravated when taking Oxbryta. It is created by eHealthMe based on reports of 24,969 people who have side effects when taking Oxbryta from the FDA, and is updated regularly.

What is Oxbryta?

Oxbryta has active ingredients of voxelotor. eHealthMe is studying from 24,969 Oxbryta users. Check the latest studies of Oxbryta.

What is Agitation aggravated?

Agitation aggravated (clinical depression in which the person exhibits irritability and restlessness) is found to be associated with 2,039 drugs and 915 conditions by eHealthMe. Check the latest studies of Agitation aggravated.

On Aug, 04, 2026

24,969 people reported to have side effects when taking Oxbryta.
Among them, 15 people (0.06%) have Agitation aggravated.

Could Oxbryta cause Agitation aggravated?

Among these 15 people:

How long have people been on Oxbryta when they have Agitation aggravated? *

  • < 1 month: 50 %
  • 1 - 6 months: 25 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 25 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Agitation aggravated when taking Oxbryta? *

  • female: 80 %
  • male: 20 %

What is the age of people who have Agitation aggravated when taking Oxbryta? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 50.0 %
  • 30-39: 33.33 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 16.67 %

What are other drugs people take besides Oxbryta? *

  1. Oxycodone: 3 people, 20.00%
  2. Hydroxyurea: 2 people, 13.33%
  3. Fentanyl: 1 person, 6.67%
  4. Deferasirox: 1 person, 6.67%

What are other side effects people have besides Agitation aggravated? *

  1. Insomnia (sleeplessness): 9 people, 60.00%
  2. Headache (pain in head): 6 people, 40.00%
  3. Pain: 5 people, 33.33%
  4. Fatigue (feeling of tiredness): 5 people, 33.33%
  5. Nausea And Vomiting: 4 people, 26.67%
  6. Nausea (feeling of having an urge to vomit): 4 people, 26.67%
  7. Sleep Disorder: 3 people, 20.00%
  8. Appetite Disorder (abnormal eating habits): 3 people, 20.00%
  9. Feeling Abnormal: 3 people, 20.00%
  10. Feeling Cold: 3 people, 20.00%

What are the existing conditions these people have? *

  1. Haemochromatosis (body to absorb more iron than usual from food): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Oxbryta and have Agitation aggravated?

- Check whether Agitation aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxbryta:

Agitation aggravated treatments and more:

How severe was Agitation aggravated and when was it recovered:

Expand to all the drugs that have ingredients of voxelotor:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Oxbryta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Agitation aggravated:

Browse all the conditions that are associated with Agitation aggravated:

How the study uses the data?

The study uses data from the FDA. It is based on voxelotor (the active ingredients of Oxbryta) and Oxbryta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.