Oxycodone and acetaminophen and Hyponatremia - a phase IV clinical study of FDA data

Summary:

Hyponatremia is reported as a side effect among people who take Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride), especially for people who are male, 60+ old, also take Famotidine, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Hyponatremia when taking Oxycodone and acetaminophen. It is created by eHealthMe based on reports of 13,404 people who have side effects when taking Oxycodone and acetaminophen from the FDA, and is updated regularly.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

What is Hyponatremia?

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 1,941 drugs and 2,272 conditions by eHealthMe. Check the latest studies of Hyponatremia.

On Jul, 15, 2026

13,404 people reported to have side effects when taking Oxycodone and acetaminophen.
Among them, 34 people (0.25%) have Hyponatremia.

Could Oxycodone and acetaminophen cause Hyponatremia?

Among these 34 people:

What is the gender of people who have Hyponatremia when taking Oxycodone and acetaminophen? *

female: 37.5 %
male: 62.5 %

What is the age of people who have Hyponatremia when taking Oxycodone and acetaminophen? *

What are other drugs people take besides Oxycodone and acetaminophen? *

What are other side effects people have besides Hyponatremia? *

Nausea (feeling of having an urge to vomit): 13 people, 38.24%
Anaemia (lack of blood): 10 people, 29.41%
Hypokalemia (low potassium): 10 people, 29.41%
Fall: 8 people, 23.53%
Pain In Jaw: 8 people, 23.53%
Pneumonia: 8 people, 23.53%
Upper Respiratory Tract Infection: 7 people, 20.59%
Nausea And Vomiting: 7 people, 20.59%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 6 people, 17.65%
Constipation: 6 people, 17.65%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 7 people, 20.59%
Neuropathy Peripheral (surface nerve damage): 6 people, 17.65%
Hypersensitivity: 5 people, 14.71%
Bone Disorder: 5 people, 14.71%
Pneumonia: 4 people, 11.76%
Anaemia (lack of blood): 4 people, 11.76%
Liver Disorder (liver diseases): 4 people, 11.76%
White Blood Cell Count Decreased: 4 people, 11.76%
Abdominal Discomfort: 4 people, 11.76%
Cough: 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and acetaminophen and have Hyponatremia?

- Check whether Hyponatremia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone and acetaminophen:

Oxycodone and acetaminophen (14,467 reports)

Hyponatremia treatments and more:

Hyponatremia (72,436 reports)

How severe was Hyponatremia and when was it recovered:

Hyponatremia in Oxycodone and acetaminophen

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Hyponatremia and drugs with ingredients of acetaminophen; oxycodone hydrochloride (502 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Oxycodone and acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatremia:

Hyponatremia (1,941 drugs)

Browse all the conditions that are associated with Hyponatremia:

Hyponatremia (2,272 conditions)

Related publications that referenced our studies

Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
Koza Y, Ta? MH, ?im?ek Z, Gündo?du F, "Hyponatremia and heart failure: the overlooked piece of the puzzle", Anatolian journal of cardiology, 2016 Jan .
Das S, Bandyopadhyay S, Ramasamy A, Prabhu VV, Pachiappan S, "A case of losartan-induced severe hyponatremia", Journal of pharmacology & pharmacotherapeutics, 2015 Jan .
Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
Kate N, Grover S, Kumar S, Modi M, "Bupropion-induced hyponatremia", General hospital psychiatry, 2013 Dec .
Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
Koza Y, Ta? MH, ?im?ek Z, Gündo?du F, "Hyponatremia and heart failure: the overlooked piece of the puzzle", Anatolian journal of cardiology, 2016 Jan .
Das S, Bandyopadhyay S, Ramasamy A, Prabhu VV, Pachiappan S, "A case of losartan-induced severe hyponatremia", Journal of pharmacology & pharmacotherapeutics, 2015 Jan .
Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
Kate N, Grover S, Kumar S, Modi M, "Bupropion-induced hyponatremia", General hospital psychiatry, 2013 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Oxycodone and acetaminophen) and Oxycodone and acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.