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Lupron and Piqray drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lupron (leuprolide acetate) and Piqray (alpelisib). Common drug interactions include alopecia among females and blood glucose increased among males.

The phase IV clinical study analyzes what interactions people have when they take Lupron and Piqray. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,122 Lupron users. Check the latest studies of Lupron.

What is Piqray?

Piqray has active ingredients of alpelisib. eHealthMe is studying from 7,290 Piqray users. Check the latest studies of Piqray.

On Jul, 24, 2026

14 people who take Lupron and Piqray together, and have interactions are studied.

Lupron and Piqray drug interactions.

What are the common drug interactions of Lupron and Piqray, by gender? *:

female:

  1. Alopecia (absence of hair from areas of the body)
  2. Arthralgia (joint pain)
  3. Drug ineffective
  4. Headache (pain in head)
  5. Metastases to central nervous system (cancer spreads to central nervous system)
  6. Myalgia (muscle pain)
  7. Rash
  8. Thirst
  9. Vision blurred
  10. Vomiting

male:

  1. Blood glucose increased
  2. Dyspepsia (indigestion)
  3. Disease progression

What are the common drug interactions of Lupron and Piqray, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Metastases to central nervous system (cancer spreads to central nervous system)
  2. Disease progression

50-59:

  1. Nausea (feeling of having an urge to vomit)
  2. Asthenia (weakness)
  3. Pain
  4. Vertigo
  5. Disease progression
  6. Drug ineffective

60+:

  1. Blood glucose increased
  2. Dyspepsia (indigestion)
  3. Disease progression

What are the existing conditions these people have? *

  1. Breast Cancer: 4 people, 28.57%
  2. Breast Cancer Female: 2 people, 14.29%
  3. Prostate Cancer: 1 person, 7.14%
  4. Metastasis (spreadable cancer to other organ from origin): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Lupron and Piqray?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lupron and Piqray:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lupron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Piqray:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lupron and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Piqray and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on leuprolide acetate and alpelisib (the active ingredients of Lupron and Piqray, respectively), and Lupron and Piqray (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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