Oxycodone and acetaminophen and Pleural effusion - a phase IV clinical study of FDA data

Summary:

Pleural effusion is reported as a side effect among people who take Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Nausea.

The phase IV clinical study analyzes which people have Pleural effusion when taking Oxycodone and acetaminophen. It is created by eHealthMe based on reports of 13,404 people who have side effects when taking Oxycodone and acetaminophen from the FDA, and is updated regularly.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

What is Pleural effusion?

Pleural effusion (water on the lungs) is found to be associated with 2,224 drugs and 3,144 conditions by eHealthMe. Check the latest studies of Pleural effusion.

On Apr, 29, 2026

13,404 people reported to have side effects when taking Oxycodone and acetaminophen.
Among them, 81 people (0.6%) have Pleural effusion.

Could Oxycodone and acetaminophen cause Pleural effusion?

Among these 81 people:

How long have people been on Oxycodone and acetaminophen when they have Pleural effusion? *

What is the gender of people who have Pleural effusion when taking Oxycodone and acetaminophen? *

female: 51.9 %
male: 48.1 %

What is the age of people who have Pleural effusion when taking Oxycodone and acetaminophen? *

What are other drugs people take besides Oxycodone and acetaminophen? *

What are other side effects people have besides Pleural effusion? *

Nausea (feeling of having an urge to vomit): 39 people, 48.15%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 32 people, 39.51%
Dyspnea (difficult or laboured breathing): 31 people, 38.27%
Hypotension (abnormally low blood pressure): 30 people, 37.04%
Constipation: 27 people, 33.33%
Cardiac Failure Congestive: 27 people, 33.33%
Cough: 27 people, 33.33%
Nausea And Vomiting: 26 people, 32.10%
Fatigue (feeling of tiredness): 26 people, 32.10%
Chest Pain: 24 people, 29.63%

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 15 people, 18.52%
Hypersensitivity: 13 people, 16.05%
High Blood Cholesterol: 13 people, 16.05%
Ventricular Extrasystoles (premature cardiac contraction): 12 people, 14.81%
Asthma: 12 people, 14.81%
Dyspnea (difficult or laboured breathing): 12 people, 14.81%
Heart Rate Irregular: 12 people, 14.81%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 12 people, 14.81%
Lung Cancer - Non-Small Cell (lung cancer): 11 people, 13.58%
Immunodeficiency Common Variable: 7 people, 8.64%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and acetaminophen and have Pleural effusion?

- Check whether Pleural effusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone and acetaminophen:

Oxycodone and acetaminophen (14,467 reports)

Pleural effusion treatments and more:

Pleural effusion (84,634 reports)

How severe was Pleural effusion and when was it recovered:

Pleural effusion in Oxycodone and acetaminophen

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Pleural effusion and drugs with ingredients of acetaminophen; oxycodone hydrochloride (1,338 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Oxycodone and acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pleural effusion:

Pleural effusion (2,224 drugs)

Browse all the conditions that are associated with Pleural effusion:

Pleural effusion (3,144 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Oxycodone and acetaminophen) and Oxycodone and acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.