Oxycontin and Hyperchlorhydria - a phase IV clinical study of FDA data

Summary:

Hyperchlorhydria is reported as a side effect among people who take Oxycontin (oxycodone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Nexium, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Hyperchlorhydria when taking Oxycontin. It is created by eHealthMe based on reports of 210,595 people who have side effects when taking Oxycontin from the FDA, and is updated regularly.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,532 Oxycontin users. Check the latest studies of Oxycontin.

What is Hyperchlorhydria?

Hyperchlorhydria (gastric acid levels are higher in stomach) is found to be associated with 455 drugs and 467 conditions by eHealthMe. Check the latest studies of Hyperchlorhydria.



On Aug, 20, 2025

210,595 people reported to have side effects when taking Oxycontin.
Among them, 10 people (0.0%) have Hyperchlorhydria.

Could Oxycontin cause Hyperchlorhydria?

Among these 10 people:

How long have people been on Oxycontin when they have Hyperchlorhydria? *

  • < 1 month: 50 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 50 %
  • 10+ years: 0.0 %

What is the gender of people who have Hyperchlorhydria when taking Oxycontin? *

  • female: 50 %
  • male: 50 %

What is the age of people who have Hyperchlorhydria when taking Oxycontin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 22.22 %
  • 50-59: 33.33 %
  • 60+: 44.44 %

What are other drugs people take besides Oxycontin? *

  1. Celebrex: 3 people, 30.00%
  2. Lyrica: 3 people, 30.00%
  3. Nexium: 3 people, 30.00%
  4. Methotrexate: 2 people, 20.00%
  5. Prednisone: 2 people, 20.00%
  6. Xanax: 2 people, 20.00%
  7. Metformin: 1 person, 10.00%
  8. Lortab: 1 person, 10.00%
  9. Lorazepam: 1 person, 10.00%
  10. Livalo: 1 person, 10.00%

What are other side effects people have besides Hyperchlorhydria? *

  1. Abdominal Pain Upper: 2 people, 20.00%
  2. Drug Ineffective: 2 people, 20.00%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 20.00%
  4. High Blood Pressure: 2 people, 20.00%
  5. Flatulence (flatus expelled through the anus): 2 people, 20.00%
  6. Insomnia (sleeplessness): 2 people, 20.00%
  7. Malaise (a feeling of general discomfort or uneasiness): 2 people, 20.00%
  8. Depression: 2 people, 20.00%
  9. Nausea (feeling of having an urge to vomit): 2 people, 20.00%
  10. Nausea And Vomiting: 2 people, 20.00%

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 20.00%
  2. Thyroid Cancer: 1 person, 10.00%
  3. Symbolic Dysfunction (a communication disorder - speech and language disorders which refer to problems in communication): 1 person, 10.00%
  4. Blood Calcium Decreased: 1 person, 10.00%
  5. Blood Pressure Abnormal: 1 person, 10.00%
  6. Bone Disorder: 1 person, 10.00%
  7. Bone Loss: 1 person, 10.00%
  8. Burning Sensation: 1 person, 10.00%
  9. Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 1 person, 10.00%
  10. Cranial Nerve Disorder (impaired functioning of one of the twelve cranial nerves): 1 person, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycontin and have Hyperchlorhydria?

- Check whether Hyperchlorhydria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycontin:

Hyperchlorhydria treatments and more:

How severe was Hyperchlorhydria and when was it recovered:

Expand to all the drugs that have ingredients of oxycodone hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Oxycontin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperchlorhydria:

Browse all the conditions that are associated with Hyperchlorhydria:

Drugs similar to Oxycontin and Hyperchlorhydria :


How the study uses the data?

The study uses data from the FDA. It is based on oxycodone hydrochloride (the active ingredients of Oxycontin) and Oxycontin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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