Ozempic and Joint stiffness - a phase IV clinical study of FDA data

Summary:

Joint stiffness is reported as a side effect among people who take Ozempic (semaglutide), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Metformin, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Joint stiffness when taking Ozempic. It is created by eHealthMe based on reports of 28,954 people who have side effects when taking Ozempic from the FDA, and is updated regularly.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,762 Ozempic users. Check the latest studies of Ozempic.

What is Joint stiffness?

Joint stiffness is found to be associated with 1,301 drugs and 1,341 conditions by eHealthMe. Check the latest studies of Joint stiffness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

28,954 people reported to have side effects when taking Ozempic.
Among them, 37 people (0.13%) have Joint stiffness.

Among these 37 people:

How long have people been on Ozempic when they have Joint stiffness? *

What is the gender of people who have Joint stiffness when taking Ozempic? *

female: 50 %
male: 50 %

What is the age of people who have Joint stiffness when taking Ozempic? *

What are other drugs people take besides Ozempic? *

Metformin: 11 people, 29.73%
Tylenol: 9 people, 24.32%
Pantoprazole: 9 people, 24.32%
Acetaminophen: 6 people, 16.22%
Methocarbamol: 6 people, 16.22%
Contrave: 6 people, 16.22%
Tamsulosin: 6 people, 16.22%
Xeljanz Xr: 6 people, 16.22%
Bupropion Hydrochloride: 6 people, 16.22%
Sertraline: 6 people, 16.22%

What are other side effects people have besides Joint stiffness? *

Joint Pain: 22 people, 59.46%
Headache (pain in head): 15 people, 40.54%
Chest Pain: 13 people, 35.14%
Nausea (feeling of having an urge to vomit): 11 people, 29.73%
Fatigue (feeling of tiredness): 11 people, 29.73%
Pain In Extremity: 11 people, 29.73%
Weight Increased: 10 people, 27.03%
High Blood Pressure: 10 people, 27.03%
Feeling Abnormal: 9 people, 24.32%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 9 people, 24.32%

What are the existing conditions these people have? *

Diabetes: 9 people, 24.32%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 24.32%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 24.32%
High Blood Cholesterol: 9 people, 24.32%
Depression: 8 people, 21.62%
High Blood Pressure: 8 people, 21.62%
Weight Decreased: 6 people, 16.22%
Type 2 Diabetes: 5 people, 13.51%
Pain: 4 people, 10.81%
Neuropathy Peripheral (surface nerve damage): 4 people, 10.81%

* Approximation only. Some reports may have incomplete information.

Do you take Ozempic and have Joint stiffness?

- Check whether Joint stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ozempic:

Ozempic (29,762 reports)

Joint stiffness treatments and more:

Joint stiffness (33,165 reports)

Browse all side effects of Ozempic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint stiffness:

Joint stiffness (1,301 drugs)

Browse all the conditions that are associated with Joint stiffness:

Joint stiffness (1,341 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on semaglutide (the active ingredients of Ozempic) and Ozempic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.