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Ozempic and Osteoporosis - a phase IV clinical study of FDA data

Summary:

Osteoporosis is reported as a side effect among people who take Ozempic (semaglutide), especially for people who are female, 60+ old, also take Truvada, and have Hiv infection.

The phase IV clinical study analyzes which people have Osteoporosis when taking Ozempic. It is created by eHealthMe based on reports of 28,954 people who have side effects when taking Ozempic from the FDA, and is updated regularly.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,761 Ozempic users. Check the latest studies of Ozempic.

What is Osteoporosis?

Osteoporosis (bones weak and more likely to break) is found to be associated with 1,810 drugs and 1,902 conditions by eHealthMe. Check the latest studies of Osteoporosis.

On Jul, 26, 2026

28,954 people reported to have side effects when taking Ozempic.
Among them, 33 people (0.11%) have Osteoporosis.

Could Ozempic cause Osteoporosis?

Among these 33 people:

What is the gender of people who have Osteoporosis when taking Ozempic? *

  • female: 53.12 %
  • male: 46.88 %

What is the age of people who have Osteoporosis when taking Ozempic? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 14.29 %
  • 50-59: 42.86 %
  • 60+: 42.86 %

What are other drugs people take besides Ozempic? *

  1. Truvada: 18 people, 54.55%
  2. Metformin: 13 people, 39.39%
  3. Lyrica: 10 people, 30.30%
  4. Biktarvy: 10 people, 30.30%
  5. Norvir: 9 people, 27.27%
  6. Triumeq: 9 people, 27.27%
  7. Descovy: 8 people, 24.24%
  8. Losartan: 8 people, 24.24%
  9. Wellbutrin: 7 people, 21.21%
  10. Prezista: 7 people, 21.21%

What are other side effects people have besides Osteoporosis? *

  1. Pain: 24 people, 72.73%
  2. Emotional Distress: 22 people, 66.67%
  3. Anhedonia (inability to experience pleasure from activities usually found enjoyable): 21 people, 63.64%
  4. Stress And Anxiety: 19 people, 57.58%
  5. Bone Density Decreased: 12 people, 36.36%
  6. Chronic Kidney Disease: 10 people, 30.30%
  7. Gait Disturbance: 8 people, 24.24%
  8. Depression: 6 people, 18.18%
  9. Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 18.18%
  10. Fatigue (feeling of tiredness): 5 people, 15.15%

What are the existing conditions these people have? *

  1. Hiv Infection: 22 people, 66.67%
  2. Type 2 Diabetes: 4 people, 12.12%
  3. Cushing's Syndrome (obesity, a rounded face, increased fat): 4 people, 12.12%
  4. High Blood Cholesterol: 3 people, 9.09%
  5. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 6.06%
  6. Oedema Peripheral (superficial swelling): 2 people, 6.06%
  7. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 6.06%
  8. Depression: 2 people, 6.06%
  9. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 6.06%
  10. Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Ozempic and have Osteoporosis?

- Check whether Osteoporosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ozempic:

Osteoporosis treatments and more:

How severe was Osteoporosis and when was it recovered:

Expand to all the drugs that have ingredients of semaglutide:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ozempic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoporosis:

Browse all the conditions that are associated with Osteoporosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on semaglutide (the active ingredients of Ozempic) and Ozempic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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