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Paliperidone and Hyponatremia - a phase IV clinical study of FDA data

Summary:

Hyponatremia is reported as a side effect among people who take Paliperidone (paliperidone), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Olanzapine, and have Schizophrenia.

The phase IV clinical study analyzes which people have Hyponatremia when taking Paliperidone. It is created by eHealthMe based on reports of 5,118 people who have side effects when taking Paliperidone from the FDA, and is updated regularly.

What is Paliperidone?

Paliperidone has active ingredients of paliperidone. eHealthMe is studying from 5,137 Paliperidone users. Check the latest studies of Paliperidone.

What is Hyponatremia?

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 1,937 drugs and 2,272 conditions by eHealthMe. Check the latest studies of Hyponatremia.

On Jul, 10, 2026

5,118 people reported to have side effects when taking Paliperidone.
Among them, 88 people (1.72%) have Hyponatremia.

Could Paliperidone cause Hyponatremia?

Among these 88 people:

How long have people been on Paliperidone when they have Hyponatremia? *

  • < 1 month: 83.33 %
  • 1 - 6 months: 16.67 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hyponatremia when taking Paliperidone? *

  • female: 32.94 %
  • male: 67.06 %

What is the age of people who have Hyponatremia when taking Paliperidone? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 12.35 %
  • 30-39: 24.69 %
  • 40-49: 19.75 %
  • 50-59: 35.8 %
  • 60+: 7.41 %

What are other drugs people take besides Paliperidone? *

  1. Olanzapine: 16 people, 18.18%
  2. Clozapine: 14 people, 15.91%
  3. Pantoprazole: 14 people, 15.91%
  4. Atropine: 13 people, 14.77%
  5. Sodium Chloride: 13 people, 14.77%
  6. Haloperidol: 11 people, 12.50%
  7. Clonazepam: 6 people, 6.82%
  8. Mirtazapine: 6 people, 6.82%
  9. Enoxaparin Sodium: 5 people, 5.68%
  10. Insulin: 3 people, 3.41%

What are other side effects people have besides Hyponatremia? *

  1. Fall: 19 people, 21.59%
  2. Paraparesis (partial paralysis of the lower limbs): 17 people, 19.32%
  3. Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 15 people, 17.05%
  4. Arrhythmias (irregular heartbeat): 14 people, 15.91%
  5. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 13 people, 14.77%
  6. Spinal Compression Fracture (fracture due to spinal compression on bone): 13 people, 14.77%
  7. Confusional State: 13 people, 14.77%
  8. Hyperhidrosis (abnormally increased sweating): 13 people, 14.77%
  9. Pain: 12 people, 13.64%
  10. Tremor (trembling or shaking movements in one or more parts of your body): 12 people, 13.64%

What are the existing conditions these people have? *

  1. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 31 people, 35.23%
  2. Bipolar Disorder (mood disorder): 9 people, 10.23%
  3. Schizoaffective Disorder (a mental disorder characterized by disordered thought): 7 people, 7.95%
  4. Diabetes: 4 people, 4.55%
  5. Catatonia (unresponsive to external stimuli): 3 people, 3.41%
  6. Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 2 people, 2.27%
  7. High Blood Pressure: 2 people, 2.27%
  8. Type 2 Diabetes: 1 person, 1.14%
  9. Mania (a state of abnormally elevated or irritable mood): 1 person, 1.14%
  10. Agitation (state of anxiety or nervous excitement): 1 person, 1.14%

* Approximation only. Some reports may have incomplete information.

Do you take Paliperidone and have Hyponatremia?

- Check whether Hyponatremia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Paliperidone:

Hyponatremia treatments and more:

How severe was Hyponatremia and when was it recovered:

Expand to all the drugs that have ingredients of paliperidone:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Paliperidone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatremia:

Browse all the conditions that are associated with Hyponatremia:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on paliperidone (the active ingredients of Paliperidone) and Paliperidone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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