Zetia and Solu-cortef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zetia (ezetimibe) and Solu-cortef (hydrocortisone sodium succinate). Common drug interactions include eschar among females and cerebral infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Zetia and Solu-cortef. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Zetia?

Zetia has active ingredients of ezetimibe. It is often used in high blood cholesterol. eHealthMe is studying from 49,113 Zetia users. Check the latest studies of Zetia.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.

On Jul, 10, 2026

12 people who take Zetia and Solu-cortef together, and have interactions are studied.

Zetia and Solu-cortef drug interactions.

What are the common drug interactions of Zetia and Solu-Cortef, by gender? *:

female:

Eschar (dead tissue that falls off (sheds) from healthy skin)
Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury)
Exostosis (formation of new bone on the surface of a bone)
Exposed bone in jaw
Facial pain
Gastritis (inflammation of stomach)
Gingival disorder (gum disease)
Gingival erosion (gum ulcer)
Haemorrhage (bleeding)
Hyperhidrosis (abnormally increased sweating)

male:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Rash
Blood glucose increased
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac arrest
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiogenic shock (inadequate circulation of blood)
Cardiomyopathy (weakening of the heart muscle)

What are the common drug interactions of Zetia and Solu-Cortef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dental plaque (film of mucus and bacteria deposited on the teeth that encourages the development of dental caries)
Dry eye (lack of adequate tears)
Dysphagia (a condition in which swallowing is difficult or painful)
Ear pain
Effusion (an escape of fluid into a body cavity)
Emotional distress
Epistaxis (bleed from the nose)
Eschar (dead tissue that falls off (sheds) from healthy skin)
Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury)
Exostosis (formation of new bone on the surface of a bone)

40-49:

Decreased appetite
Depression
Disseminated cryptococcosis (one of the acquired immune deficiency syndrome defining criteria and the most common cause of life threatening meningitis)
Dyspepsia (indigestion)
Dyspnoea exertional (breathlessness or shortness of breath)
Haematuria (presence of blood in urine)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Insomnia (sleeplessness)
Onychomycosis (fungal infection of the nail)
Oral candidiasis (fungal infection of mouth)

50-59:

Acute myocardial infarction (acute heart attack)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Atelectasis (partial or complete collapse of the lung)
Blood glucose increased
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac arrest
Cardiac failure congestive

60+:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Rash
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults)
Infusion related reaction
Nausea (feeling of having an urge to vomit)
Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Septic shock (shock due to blood infection)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Wheezing (a high-pitched whistling sound made while you breath): 2 people, 16.67%
Heparin-Induced Thrombocytopenia: 2 people, 16.67%
Pain: 2 people, 16.67%
Muscle Spasms (muscle contraction): 2 people, 16.67%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 16.67%
Dyspnea (difficult or laboured breathing): 2 people, 16.67%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 8.33%
Breast Cancer Metastatic: 1 person, 8.33%
Cardiac Failure: 1 person, 8.33%
Cardiomyopathy (weakening of the heart muscle): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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