Pantoprazole and Epidermal necrosis - a phase IV clinical study of FDA data

Summary:

Epidermal necrosis is reported as a side effect among people who take Pantoprazole (pantoprazole sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Folic Acid, and have Folate deficiency.

The phase IV clinical study analyzes which people have Epidermal necrosis when taking Pantoprazole. It is created by eHealthMe based on reports of 281,696 people who have side effects when taking Pantoprazole from the FDA, and is updated regularly.

What is Pantoprazole?

Pantoprazole has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 285,165 Pantoprazole users. Check the latest studies of Pantoprazole.

What is Epidermal necrosis?

Epidermal necrosis (skin condition that is usually caused by a reaction to drugs) is found to be associated with 142 drugs and 318 conditions by eHealthMe. Check the latest studies of Epidermal necrosis.

On Jul, 16, 2026

281,696 people reported to have side effects when taking Pantoprazole.
Among them, 24 people (0.01%) have Epidermal necrosis.

Could Pantoprazole cause Epidermal necrosis?

Among these 24 people:

How long have people been on Pantoprazole when they have Epidermal necrosis? *

What is the gender of people who have Epidermal necrosis when taking Pantoprazole? *

female: 69.57 %
male: 30.43 %

What is the age of people who have Epidermal necrosis when taking Pantoprazole? *

What are other drugs people take besides Pantoprazole? *

What are other side effects people have besides Epidermal necrosis? *

Rash Maculo-Papular (red area on the skin that is covered with small confluent bumps): 9 people, 37.50%
Nephropathy Toxic (damage to kidney due to toxins): 7 people, 29.17%
Fever: 6 people, 25.00%
Bone Marrow Failure: 6 people, 25.00%
Skin Erosion (a discontinuity of the skin): 6 people, 25.00%
Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 20.83%
Rashes (redness): 5 people, 20.83%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 5 people, 20.83%
C-Reactive Protein Increased: 5 people, 20.83%
Procalcitonin Increased: 4 people, 16.67%

What are the existing conditions these people have? *

Folate Deficiency (lack of folic acid): 9 people, 37.50%
Psoriasis (immune-mediated disease that affects the skin): 7 people, 29.17%
Stress And Anxiety: 2 people, 8.33%
Ill-Defined Disorder: 2 people, 8.33%
Endocarditis (inflammation in heart muscle): 2 people, 8.33%
Cardiac Failure: 2 people, 8.33%
Respiratory Disorder (respiratory disease): 1 person, 4.17%
Pneumonia: 1 person, 4.17%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 1 person, 4.17%
Affective Disorder (mental disorder): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Pantoprazole and have Epidermal necrosis?

- Check whether Epidermal necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pantoprazole:

Pantoprazole (285,165 reports)

Browse all side effects of Pantoprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Epidermal necrosis:

Epidermal necrosis (142 drugs)

Browse all the conditions that are associated with Epidermal necrosis:

Epidermal necrosis (318 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Pantoprazole) and Pantoprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.