Pantoprazole and Heart valve surgery - a phase IV clinical study of FDA data

Summary:

Heart valve surgery is reported as a side effect among people who take Pantoprazole (pantoprazole sodium), especially for people who are male, 60+ old, also take Spiriva, and have Crohn's disease.

The phase IV clinical study analyzes which people have Heart valve surgery when taking Pantoprazole. It is created by eHealthMe based on reports of 281,696 people who have side effects when taking Pantoprazole from the FDA, and is updated regularly.

What is Pantoprazole?

Pantoprazole has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 285,165 Pantoprazole users. Check the latest studies of Pantoprazole.

What is Heart valve surgery?

Heart valve surgery is found to be associated with 151 drugs and 437 conditions by eHealthMe. Check the latest studies of Heart valve surgery.

On Jul, 14, 2026

281,696 people reported to have side effects when taking Pantoprazole.
Among them, 27 people (0.01%) have Heart valve surgery.

Could Pantoprazole cause Heart valve surgery?

Among these 27 people:

What is the gender of people who have Heart valve surgery when taking Pantoprazole? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Heart valve surgery when taking Pantoprazole? *

What are other drugs people take besides Pantoprazole? *

What are other side effects people have besides Heart valve surgery? *

Fatigue (feeling of tiredness): 10 people, 37.04%
Abdominal Pain: 7 people, 25.93%
Hospitalisation: 7 people, 25.93%
Haematochezia (passage of stools containing blood): 7 people, 25.93%
Insomnia (sleeplessness): 6 people, 22.22%
Anorectal Discomfort: 6 people, 22.22%
Dyspnea (difficult or laboured breathing): 5 people, 18.52%
Nasopharyngitis (inflammation of the nasopharynx): 4 people, 14.81%
Oropharyngeal Discomfort (pain or irritation of oropharynx): 4 people, 14.81%
Productive Cough: 4 people, 14.81%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 25.93%
High Blood Pressure: 3 people, 11.11%
Parkinson's Disease: 3 people, 11.11%
Ovarian Cancer (cancer of ovary): 3 people, 11.11%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 7.41%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 7.41%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 7.41%
Pain: 1 person, 3.70%
Dyspnea (difficult or laboured breathing): 1 person, 3.70%
Arrhythmias (irregular heartbeat): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Pantoprazole and have Heart valve surgery?

- Check whether Heart valve surgery is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pantoprazole:

Pantoprazole (285,165 reports)

Browse all side effects of Pantoprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart valve surgery:

Heart valve surgery (151 drugs)

Browse all the conditions that are associated with Heart valve surgery:

Heart valve surgery (437 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Pantoprazole) and Pantoprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.